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Gene Review

ALOXE3  -  arachidonate lipoxygenase 3

Homo sapiens

Synonyms: ARCI3, E-LOX, Epidermal LOX-3, Epidermis-type lipoxygenase 3, Hydroperoxide isomerase ALOXE3, ...
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Disease relevance of ALOXE3


High impact information on ALOXE3


Regulatory relationships of ALOXE3


Other interactions of ALOXE3


  1. Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1. Jobard, F., Lefèvre, C., Karaduman, A., Blanchet-Bardon, C., Emre, S., Weissenbach, J., Ozgüc, M., Lathrop, M., Prud'homme, J.F., Fischer, J. Hum. Mol. Genet. (2002) [Pubmed]
  2. Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis. Eckl, K.M., Krieg, P., Küster, W., Traupe, H., André, F., Wittstruck, N., Fürstenberger, G., Hennies, H.C. Hum. Mutat. (2005) [Pubmed]
  3. The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase. Yu, Z., Schneider, C., Boeglin, W.E., Marnett, L.J., Brash, A.R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. The clinical spectrum of nonbullous congenital ichthyosiform erythroderma and lamellar ichthyosis. Akiyama, M., Sawamura, D., Shimizu, H. Clin. Exp. Dermatol. (2003) [Pubmed]
  5. A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. Krieg, P., Marks, F., Fürstenberger, G. Genomics (2001) [Pubmed]
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