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Gene Review:

Spry2 - sprouty homolog 2 (Drosophila)

Mus musculus

Synonyms: Protein sprouty homolog 2, Spry-2, sprouty2

Lin, W. et al., Taketomi, T. et al., Davidson, B.P. et al., Peterson, K.A. et al., Shim, K. et al.

Davidson, Cheng, Kinder, Tam,

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Disease relevance of Spry2

We report here that loss of the Sprouty2 gene (also known as Spry2) in mice resulted in enteric nerve hyperplasia, which led to esophageal achalasia and intestinal pseudo-obstruction [1].
Both this cell fate change and hearing loss can be partially rescued by reducing Fgf8 gene dosage in Spry2 null mutant mice [2].

High impact information on Spry2

The early response associated with the expression of Spry2 suggests that the later phenotype observed could be primarily related to an inhibition of the FGF signaling pathway [3].
These expression profiles indicate that Fgf8, Spry2 and Sef belong to a synexpression group and suggest that these genes may functionally interact during embryonic development [4].
Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis [4].
The candidate genes identified include Phr1 (formerly Pam) and Spry2, which are mouse homologs of genes required for development in Drosophila melanogaster [5].

References

Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Taketomi, T., Yoshiga, D., Taniguchi, K., Kobayashi, T., Nonami, A., Kato, R., Sasaki, M., Sasaki, A., Ishibashi, H., Moriyama, M., Nakamura, K., Nishimura, J., Yoshimura, A. Nat. Neurosci. (2005) [Pubmed]
Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling. Shim, K., Minowada, G., Coling, D.E., Martin, G.R. Dev. Cell (2005) [Pubmed]
Exogenous FGF-4 can suppress anterior development in the mouse embryo during neurulation and early organogenesis. Davidson, B.P., Cheng, L., Kinder, S.J., Tam, P.P. Dev. Biol. (2000) [Pubmed]
Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis. Lin, W., Fürthauer, M., Thisse, B., Thisse, C., Jing, N., Ang, S.L. Mech. Dev. (2002) [Pubmed]
Functional and comparative genomic analysis of the piebald deletion region of mouse chromosome 14. Peterson, K.A., King, B.L., Hagge-Greenberg, A., Roix, J.J., Bult, C.J., O'Brien, T.P. Genomics (2002) [Pubmed]

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SPRY2	Bos taurus
SPRY2	Canis lupus familiaris
spry2	Danio rerio
SPRY2	Gallus gallus
SPRY2	Homo sapiens
SPRY2	Macaca mulatta
SPRY2	Pan troglodytes
Spry2	Rattus norvegicus
spry2	Xenopus (Silurana) tropicalis

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