The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Spry2  -  sprouty homolog 2 (Drosophila)

Mus musculus

Synonyms: Protein sprouty homolog 2, Spry-2, sprouty2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Spry2


High impact information on Spry2

  • The early response associated with the expression of Spry2 suggests that the later phenotype observed could be primarily related to an inhibition of the FGF signaling pathway [3].
  • These expression profiles indicate that Fgf8, Spry2 and Sef belong to a synexpression group and suggest that these genes may functionally interact during embryonic development [4].
  • Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis [4].
  • The candidate genes identified include Phr1 (formerly Pam) and Spry2, which are mouse homologs of genes required for development in Drosophila melanogaster [5].


  1. Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Taketomi, T., Yoshiga, D., Taniguchi, K., Kobayashi, T., Nonami, A., Kato, R., Sasaki, M., Sasaki, A., Ishibashi, H., Moriyama, M., Nakamura, K., Nishimura, J., Yoshimura, A. Nat. Neurosci. (2005) [Pubmed]
  2. Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling. Shim, K., Minowada, G., Coling, D.E., Martin, G.R. Dev. Cell (2005) [Pubmed]
  3. Exogenous FGF-4 can suppress anterior development in the mouse embryo during neurulation and early organogenesis. Davidson, B.P., Cheng, L., Kinder, S.J., Tam, P.P. Dev. Biol. (2000) [Pubmed]
  4. Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis. Lin, W., Fürthauer, M., Thisse, B., Thisse, C., Jing, N., Ang, S.L. Mech. Dev. (2002) [Pubmed]
  5. Functional and comparative genomic analysis of the piebald deletion region of mouse chromosome 14. Peterson, K.A., King, B.L., Hagge-Greenberg, A., Roix, J.J., Bult, C.J., O'Brien, T.P. Genomics (2002) [Pubmed]
WikiGenes - Universities