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Gene Review

Il17rd  -  interleukin 17 receptor D

Mus musculus

Synonyms: 2810004A10Rik, AI428510, IL-17 receptor D, IL-17RD, Il17rlm, ...
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High impact information on Il17rd

  • Therefore, alternative splicing of the hSef gene expands the Sef feedback inhibition repertoire of RTK signaling [1].
  • Sef was recently identified as a negative regulator of fibroblast growth factor (FGF) signaling in a genetic screen of zebrafish and subsequently in mouse and humans [2].
  • Furthermore, our data suggested Sef exerted the negative effect on FGF2-induced PC-12 cell differentiation through the prevention of Ras-mitogen-activated protein kinase signaling, possibly functioning upstream of the Ras molecule [3].
  • We provide evidence that the Sef gene products were located mainly on the cell membrane [3].
  • By repressing events upstream and/or downstream Ras, Sef inhibits FGF-induced ERK activation and cell proliferation [4].

Biological context of Il17rd


Anatomical context of Il17rd


Regulatory relationships of Il17rd

  • Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain region [6].


  1. Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity. Preger, E., Ziv, I., Shabtay, A., Sher, I., Tsang, M., Dawid, I.B., Altuvia, Y., Ron, D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Sef interacts with TAK1 and mediates JNK activation and apoptosis. Yang, X., Kovalenko, D., Nadeau, R.J., Harkins, L.K., Mitchell, J., Zubanova, O., Chen, P.Y., Friesel, R. J. Biol. Chem. (2004) [Pubmed]
  3. hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling. Xiong, S., Zhao, Q., Rong, Z., Huang, G., Huang, Y., Chen, P., Zhang, S., Liu, L., Chang, Z. J. Biol. Chem. (2003) [Pubmed]
  4. Sef-S, an alternative splice isoform of sef gene, inhibits NIH3T3 cell proliferation via a mitogen-activated protein kinases p42 and p44 (ERK1/2)-independent mechanism. Rong, Z., Ren, Y., Cheng, L., Li, Z., Li, Y., Sun, Y., Li, H., Xiong, S., Chang, Z. Cell. Signal. (2007) [Pubmed]
  5. Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis. Lin, W., Fürthauer, M., Thisse, B., Thisse, C., Jing, N., Ang, S.L. Mech. Dev. (2002) [Pubmed]
  6. Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain region. Lin, W., Jing, N., Basson, M.A., Dierich, A., Licht, J., Ang, S.L. Genesis (2005) [Pubmed]
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