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Gene Review

Mst1  -  Macrophage stimulating 1 (hepatocyte...

Rattus norvegicus

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High impact information on Mst1

  • CONCLUSIONS: Our results suggest that Mst1 plays an important role in the induction of apoptosis of VSMCs, mediating the vascular remodeling process, and may be a potential therapeutic target for vascular proliferative diseases [1].
  • Adenovirus-mediated overexpression of wild-type Mst1 (AdMst1) in VSMCs increased apoptotic cells with activation of caspase 3 [1].
  • Mst1 is a ubiquitously expressed serine/threonine kinase known to be activated in response to a wide variety of nonphysiological apoptotic stimuli [1].
  • Mst1 was induced and activated in the balloon-injured rat carotid artery [1].


  1. Critical role of Mst1 in vascular remodeling after injury. Ono, H., Ichiki, T., Ohtsubo, H., Fukuyama, K., Imayama, I., Hashiguchi, Y., Sadoshima, J., Sunagawa, K. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
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