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Gene Review

Mst1  -  macrophage stimulating 1 (hepatocyte...

Mus musculus

Synonyms: D3F15S2h, D9H3F15S2, DNF15S2h, Hepatocyte growth factor-like protein, Hgfl, ...
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Disease relevance of Mst1


High impact information on Mst1


Chemical compound and disease context of Mst1


Biological context of Mst1


Anatomical context of Mst1

  • Using the MEK inhibitor PD98059, we show that the activation of ERK is required for the enhanced BFU-E formation in response to MSP [7].
  • The expanded progenitor cells express STK and respond to MSP in a colony assay [7].
  • To evaluate the signals induced by MSP/STK in primary erythroid progenitor cells, we adapted a method for the expansion of murine bone marrow mononuclear cells [7].
  • MSP mRNA expression increases with age in sensory neuron targets and decreases in sympathetic targets [9].
  • Taken together, these results suggest that MSP may actively suppress cell-mediated immune responses through its ability to down-regulate IL-12 production and thus inhibit classical activation of macrophages [10].

Associations of Mst1 with chemical compounds


Regulatory relationships of Mst1

  • We also show that the ability of MSP to inhibit IL-12 production is independent of IL-10 [10].
  • We report that Ron mRNA is expressed by NGF-dependent sensory and sympathetic neurons and that these neurons survive and grow with MSP at different stages of development [9].

Other interactions of Mst1

  • In this study we demonstrate that pretreatment of macrophages with MSP before IFN-gamma and LPS results in the complete inhibition of IL-12 production due to suppression of p40 expression [10].
  • MSP pretreatment of macrophages resulted in decreased tyrosine phosphorylation of Stat-1 and decreased expression of IFN consensus sequence binding protein in response to inflammatory cytokines [10].
  • These results show that MSP is a target-derived neurotrophic factor for subsets of sensory and sympathetic neurons at different times during their development [9].
  • Our lab and others have previously shown that macrophage-stimulating protein (MSP), through activation of its receptor RON, negatively regulates NO production in response to IFN-gamma and LPS by inhibiting the expression of inducible NO synthase (iNOS) [8].
  • Expression of other genes associated with alternative activation, including scavenger receptor A and IL-1R antagonist, is also up-regulated in MSP-stimulated murine macrophages [8].

Analytical, diagnostic and therapeutic context of Mst1


  1. Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. Yamamoto, S., Yang, G., Zablocki, D., Liu, J., Hong, C., Kim, S.J., Soler, S., Odashima, M., Thaisz, J., Yehia, G., Molina, C.A., Yatani, A., Vatner, D.E., Vatner, S.F., Sadoshima, J. J. Clin. Invest. (2003) [Pubmed]
  2. STK receptor tyrosine kinase regulates susceptibility to infection with Listeria monocytogenes. Lutz, M.A., Gervais, F., Bernstein, A., Hattel, A.L., Correll, P.H. Infect. Immun. (2002) [Pubmed]
  3. Histone modifications associated with somatic hypermutation. Odegard, V.H., Kim, S.T., Anderson, S.M., Shlomchik, M.J., Schatz, D.G. Immunity (2005) [Pubmed]
  4. Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells. Kurihara, N., Iwama, A., Tatsumi, J., Ikeda, K., Suda, T. Blood (1996) [Pubmed]
  5. MDHM, a macrophage-stimulatory product of Mycoplasma fermentans, leads to in vitro interleukin-1 (IL-1), IL-6, tumor necrosis factor, and prostaglandin production and is pyrogenic in rabbits. Mühlradt, P.F., Schade, U. Infect. Immun. (1991) [Pubmed]
  6. Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9. Degen, S.J., Gilbert, D.J., Jenkins, N.A., Copeland, N.G. Genomics (1992) [Pubmed]
  7. Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells. Teal, H.E., Craici, A., Paulson, R.F., Correll, P.H. J. Hematother. Stem Cell Res. (2003) [Pubmed]
  8. Activation of the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase by macrophage-stimulating protein results in the induction of arginase activity in murine peritoneal macrophages. Morrison, A.C., Correll, P.H. J. Immunol. (2002) [Pubmed]
  9. Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons. Forgie, A., Wyatt, S., Correll, P.H., Davies, A.M. Development (2003) [Pubmed]
  10. Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide. Morrison, A.C., Wilson, C.B., Ray, M., Correll, P.H. J. Immunol. (2004) [Pubmed]
  11. Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. Reszka, A.A., Halasy-Nagy, J.M., Masarachia, P.J., Rodan, G.A. J. Biol. Chem. (1999) [Pubmed]
  12. Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor. Santoro, M.M., Gaudino, G., Villa-Moruzzi, E. Biochem. J. (2003) [Pubmed]
  13. Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity. Muhlradt, P.F., Sasse, F. Cancer Res. (1997) [Pubmed]
  14. Biodegradable microspheres. V: Stimulation of macrophages with microparticles made of various polysaccharides. Artursson, P., Arro, E., Edman, P., Ericsson, J.L., Sjöholm, I. Journal of pharmaceutical sciences. (1987) [Pubmed]
  15. Macrophage stimulating protein is a novel neurotrophic factor. Stella, M.C., Vercelli, A., Repici, M., Follenzi, A., Comoglio, P.M. Mol. Biol. Cell (2001) [Pubmed]
  16. Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system. Ohshiro, K., Iwama, A., Matsuno, K., Ezaki, T., Sakamoto, O., Hamaguchi, I., Takasu, N., Suda, T. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  17. Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase, a receptor for macrophage-stimulating protein. Iwama, A., Wang, M.H., Yamaguchi, N., Ohno, N., Okano, K., Sudo, T., Takeya, M., Gervais, F., Morissette, C., Leonard, E.J., Suda, T. Blood (1995) [Pubmed]
  18. Hepatic catabolism of intravenously administered pro-macrophage-stimulating protein in mice. Leonard, E.J., Skeel, A. J. Leukoc. Biol. (1996) [Pubmed]
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