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Gene Review:

Ppp1cc - protein phosphatase 1, catalytic subunit,...

Rattus norvegicus

Synonyms: PP-1G, Ppp1cc1, Protein phosphatase 1C catalytic subunit, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Ragolia, L. et al., Moorhead, G. et al., Ragolia, L. et al., Ragolia, L. et al.

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High impact information on Ppp1cc

To further confirm the role of PP-1, we used L6 cell lines that overexpress the glycogen/SR-associated regulatory subunit of PP-1, PP-1G [1].
In this report functional studies were performed on rat skeletal muscle L6 cells stably transfected with an Asp905Tyr mutant PP-1G to evaluate the impact of this mutation on cellular responsiveness to insulin and cAMP [2].
Although transfection resulted in a 3-fold increase in mutant PP-1G subunit expression, basal and insulin-stimulated PP-1 catalytic activities were decreased when compared with L6 cells transfected with wild-type PP-1G [2].
The glycogen-associated regulatory subunit of protein phosphatase-1 (PP-1G) plays a major role in insulin-stimulated glycogen synthesis and thus the regulation of nonoxidative glucose disposal in skeletal muscle [2].
In a general population of Caucasians a polymorphism at codon 905 of PP-1G from an aspartate to tyrosine has been reported to be associated with insulin resistance and hypersecretion [2].

Biological context of Ppp1cc

Stimulation of PP-1 is accompanied by the phosphorylation of a 160-kDa regulatory subunit of PP-1 (PP-1G) [3].

Analytical, diagnostic and therapeutic context of Ppp1cc

The form of protein phosphatase-1 associated with hepatic glycogen (PP1G) was purified to near homogeneity from rat liver by affinity chromatography on microcystin-Sepharose and gel-filtration [4].

References

Role of serine/threonine protein phosphatases in insulin regulation of Na+/K+-ATPase activity in cultured rat skeletal muscle cells. Ragolia, L., Cherpalis, B., Srinivasan, M., Begum, N. J. Biol. Chem. (1997) [Pubmed]
Effect of an Asp905Tyr mutation of the glycogen-associated regulatory subunit of protein phosphatase-1 on the regulation of glycogen synthesis by insulin and cyclic adenosine 3',5'-monophosphate agonists. Ragolia, L., Duddy, N., Begum, N. Mol. Endocrinol. (1999) [Pubmed]
The effect of modulating the glycogen-associated regulatory subunit of protein phosphatase-1 on insulin action in rat skeletal muscle cells. Ragolia, L., Begum, N. Endocrinology (1997) [Pubmed]
Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography. Moorhead, G., MacKintosh, C., Morrice, N., Cohen, P. FEBS Lett. (1995) [Pubmed]

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TOPP1	Arabidopsis thaliana
Ppp1cc	Mus musculus
Os08g0455600	Oryza sativa Japonica Group

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