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Gene Review

CENPI  -  centromere protein I

Homo sapiens

Synonyms: CENP-I, Centromere protein I, FSH primary response protein 1, FSHPRH1, Follicle-stimulating hormone primary response protein, ...
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High impact information on CENPI

  • The level of LRPR1 mRNA was very low in Sertoli cells isolated from 21-day-old rats and cultured for 3 days in the absence of FSH, but LRPR1 mRNA expression was markedly increased within 2 h after addition of FSH to these cultures [1].
  • The up-regulation of LRPR1 mRNA expression by FSH was also observed in the presence of the protein synthesis inhibitor cycloheximide, indicating that FSH regulates LRPR1 mRNA expression through a direct mechanism which does not require de novo protein synthesis [1].
  • Dibutyryl-cyclic AMP [(Bu)2cAMP] and forskolin had similar effects compared to FSH, indicating that cAMP acts as a second messenger in the regulation of LRPR1 expression [1].
  • LRPR1 mRNA expression is relatively high in testis, ovary and spleen [1].
  • Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein [1].

Anatomical context of CENPI

  • Thus, LRPR1 represents a primary response gene in FSH action on Sertoli cells [1].


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