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Gene Review

FCER1A  -  Fc fragment of IgE, high affinity I,...

Homo sapiens

Synonyms: FCE1A, Fc-epsilon RI-alpha, FcERI, High affinity immunoglobulin epsilon receptor subunit alpha, IgE Fc receptor subunit alpha
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Disease relevance of FCER1A


High impact information on FCER1A


Biological context of FCER1A


Anatomical context of FCER1A


Associations of FCER1A with chemical compounds


Physical interactions of FCER1A

  • The large surface area of IgE and Fc epsilon RI alpha that is implicated in complex formation from previous mutagenesis studies on the two proteins may account in part for the magnitude of Delta Cp degrees [19].

Regulatory relationships of FCER1A


Other interactions of FCER1A

  • Within this contig a 1.1-Mb BAC and PAC core segment joining CD1D to FCER1A was fully sequenced and thoroughly analyzed [22].
  • Further experiments revealed that these Fc epsilon RI alpha gamma-expressing cells closely resemble peripheral blood DC by immunophenotype (HLA-DRhigh, HLA-DQhhigh; CD4+, CD11a+, CD32+, CD33+, B7/2 (CD86)+; CD11blow, CD14low, CD40low, CD54low, CD64low) and cell morphology [11].
  • CD54 and Fc epsilon RI alpha also were expressed constitutively [23].
  • Induction of Fc epsilon RI alpha mRNA and protein synthesis by interleukin 4 in CD34+ cells-derived CD1a+ dendritic cells [24].
  • CONCLUSION: Two different pathways by which Fc epsilon RI alpha-chain expression was modulated in BMs were identified: (1) the enhancing effect of IL-4 and IL-13 and (2) the inhibitory effect of GCs [16].

Analytical, diagnostic and therapeutic context of FCER1A


  1. Novel exon 2A of the high-affinity receptor for the IgE alpha-chain gene (FCER1A) and autoimmunity in patients with asthma or urticaria. Potaczek, D.P., Sanak, M., Nizankowska, E., Mastalerz, L., Dziedzina, S., Grzywacz, M., Szczeklik, A. Ann. Allergy Asthma Immunol. (2006) [Pubmed]
  2. Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions. Fung-Leung, W.P., De Sousa-Hitzler, J., Ishaque, A., Zhou, L., Pang, J., Ngo, K., Panakos, J.A., Chourmouzis, E., Liu, F.T., Lau, C.Y. J. Exp. Med. (1996) [Pubmed]
  3. Intracellular expression and release of Fc epsilon RI alpha by human eosinophils. Seminario, M.C., Saini, S.S., MacGlashan, D.W., Bochner, B.S. J. Immunol. (1999) [Pubmed]
  4. Affinity improvement of the high-affinity immunoglobulin E receptor by phage display. Iwasaki, A., Doi, T., Umetani, M., Watanabe, M., Suda, M., Hattori, Y., Nagoya, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  5. Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI). Bieber, T., de la Salle, H., Wollenberg, A., Hakimi, J., Chizzonite, R., Ring, J., Hanau, D., de la Salle, C. J. Exp. Med. (1992) [Pubmed]
  6. Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors. Novak, N., Tepel, C., Koch, S., Brix, K., Bieber, T., Kraft, S. J. Clin. Invest. (2003) [Pubmed]
  7. Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. Pang, J., Taylor, G.R., Munroe, D.G., Ishaque, A., Fung-Leung, W.P., Lau, C.Y., Liu, F.T., Zhou, L. J. Immunol. (1993) [Pubmed]
  8. Identification of sites on the human Fc epsilon RI alpha subunit which are involved in binding human and rat IgE. Mallamaci, M.A., Chizzonite, R., Griffin, M., Nettleton, M., Hakimi, J., Tsien, W.H., Kochan, J.P. J. Biol. Chem. (1993) [Pubmed]
  9. Functional characterization of the signal transduction events mediated by Fc epsilon RI alpha and gamma chimeric receptors. Repetto, B., Bandara, G., Wiggan, G.A., Gilfillan, A.M., Kochan, J.P. Int. Arch. Allergy Immunol. (1995) [Pubmed]
  10. Peroxisome proliferator-activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells. Fujimura, Y., Tachibana, H., Yamada, K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  11. Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. Maurer, D., Fiebiger, S., Ebner, C., Reininger, B., Fischer, G.F., Wichlas, S., Jouvin, M.H., Schmitt-Egenolf, M., Kraft, D., Kinet, J.P., Stingl, G. J. Immunol. (1996) [Pubmed]
  12. Surface expression of Fc epsilon RI on Langerhans' cells of clinically uninvolved skin is associated with disease activity in atopic dermatitis, allergic asthma, and rhinitis. Semper, A.E., Heron, K., Woollard, A.C., Kochan, J.P., Friedmann, P.S., Church, M.K., Reischl, I.G. J. Allergy Clin. Immunol. (2003) [Pubmed]
  13. Quantitation of tryptase, chymase, Fc epsilon RI alpha, and Fc epsilon RI gamma mRNAs in human mast cells and basophils by competitive reverse transcription-polymerase chain reaction. Xia, H.Z., Kepley, C.L., Sakai, K., Chelliah, J., Irani, A.M., Schwartz, L.B. J. Immunol. (1995) [Pubmed]
  14. Purification and characterization of human recombinant IgE-Fc fragments that bind to the human high affinity IgE receptor. Basu, M., Hakimi, J., Dharm, E., Kondas, J.A., Tsien, W.H., Pilson, R.S., Lin, P., Gilfillan, A., Haring, P., Braswell, E.H. J. Biol. Chem. (1993) [Pubmed]
  15. Levels of tryptase, chymase, and Fc epsilon RI alpha messenger RNA in human skin are unchanged after IgE-dependent stimulation of cutaneous mast cells in vivo. Xia, H.Z., Zweiman, B., Schwartz, L.B. J. Allergy Clin. Immunol. (1997) [Pubmed]
  16. Modulation of high-affinity IgE receptor expression in blood monocytes: opposite effect of IL-4 and glucocorticoids. Gosset, P., Lamblin-Degros, C., Tillie-Leblond, I., Charbonnier, A.S., Joseph, M., Wallaert, B., Kochan, J.P., Tonnel, A.B. J. Allergy Clin. Immunol. (2001) [Pubmed]
  17. Role of glycosylation sites in the IgE Fc molecule. Nettleton, M.Y., Kochan, J.P. Int. Arch. Allergy Immunol. (1995) [Pubmed]
  18. Characterization of a human basophil-like cell line (LAMA-84). Blom, T., Nilsson, G., Sundström, C., Nilsson, K., Hellman, L. Scand. J. Immunol. (1996) [Pubmed]
  19. Thermodynamics of the interaction of human immunoglobulin E with its high-affinity receptor Fc epsilon RI. Keown, M.B., Henry, A.J., Ghirlando, R., Sutton, B.J., Gould, H.J. Biochemistry (1998) [Pubmed]
  20. Basophilic differentiation of the human leukemia cell line KU812 upon treatment with interleukin-4. Hara, T., Yamada, K., Tachibana, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  21. Expression of high-affinity IgE receptor (Fc epsilon RI) on human alveolar macrophages from atopic and non-atopic patients. Ochiai, K., Kagami, M., Umemiya, K., Matsumura, R., Kawashima, T., Tomioka, H. Int. Arch. Allergy Immunol. (1996) [Pubmed]
  22. Genomic anatomy of a premier major histocompatibility complex paralogous region on chromosome 1q21-q22. Shiina, T., Ando, A., Suto, Y., Kasai, F., Shigenari, A., Takishima, N., Kikkawa, E., Iwata, K., Kuwano, Y., Kitamura, Y., Matsuzawa, Y., Sano, K., Nogami, M., Kawata, H., Li, S., Fukuzumi, Y., Yamazaki, M., Tashiro, H., Tamiya, G., Kohda, A., Okumura, K., Ikemura, T., Soeda, E., Mizuki, N., Kimura, M., Bahram, S., Inoko, H. Genome Res. (2001) [Pubmed]
  23. Characterization of 'adult-type' mast cells derived from human bone marrow CD34(+) cells cultured in the presence of stem cell factor and interleukin-6. Interleukin-4 is not required for constitutive expression of CD54, Fc epsilon RI alpha and chymase, and CD13 expression is reduced during differentiation. Shimizu, Y., Sakai, K., Miura, T., Narita, T., Tsukagoshi, H., Satoh, Y., Ishikawa, S., Morishita, Y., Takai, S., Miyazaki, M., Mori, M., Saito, H., Xia, H., Schwartz, L.B. Clin. Exp. Allergy (2002) [Pubmed]
  24. Induction of Fc epsilon RI alpha mRNA and protein synthesis by interleukin 4 in CD34+ cells-derived CD1a+ dendritic cells. Magerstaedt, R., Kraft, S., Strobel, I., Jürgens, M., Hanau, D., Wessendorf, J., Bieber, T. Adv. Exp. Med. Biol. (1997) [Pubmed]
  25. Hydrodynamic studies of a complex between the Fc fragment of human IgE and a soluble fragment of the Fc epsilon RI alpha chain. Keown, M.B., Ghirlando, R., Young, R.J., Beavil, A.J., Owens, R.J., Perkins, S.J., Sutton, B.J., Gould, H.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  26. Human neutrophils express the high-affinity receptor for immunoglobulin E (Fc epsilon RI): role in asthma. Gounni, A.S., Lamkhioued, B., Koussih, L., Ra, C., Renzi, P.M., Hamid, Q. FASEB J. (2001) [Pubmed]
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