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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IPMK  -  inositol polyphosphate multikinase

Homo sapiens

Synonyms: IMPK, Inositol 1,3,4,6-tetrakisphosphate 5-kinase, Inositol polyphosphate multikinase
 
 
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High impact information on IPMK

  • Inositol-1,4,5-trisphosphate 3-kinases (IP3K) A, B, and C as well as inositol polyphosphate multikinase (IPMK) catalyze the first step in the formation of the higher phosphorylated inositols InsP5 and InsP6 by metabolizing Ins(1,4,5)P3 to Ins(1,3,4,5)P4 [1].
  • We identified chlorogenic acid as a specific IPMK inhibitor whereas the flavonoids myricetin, 3',4',7,8-tetrahydroxyflavone and EGCG inhibit preferentially IP3K-A and IP3K-C [1].
  • Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase [1].
  • Small molecules targeting CSNK1G3 and/or IPMK in addition to Akt may thus exhibit increased efficacy and have the potential for improved therapeutic index [2].
  • Functionally important motifs [inositol phosphate-binding site, ATP-binding site, catalytically important SSLL (Ser-Ser-Leu-Leu) domain] are conserved between the human IPMK and yeast ArgRIII [3].
 

Biological context of IPMK

 

Associations of IPMK with chemical compounds

References

  1. Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase. Mayr, G.W., Windhorst, S., Hillemeier, K. J. Biol. Chem. (2005) [Pubmed]
  2. RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors. Morgan-Lappe, S., Woods, K.W., Li, Q., Anderson, M.G., Schurdak, M.E., Luo, Y., Giranda, V.L., Fesik, S.W., Leverson, J.D. Oncogene (2006) [Pubmed]
  3. The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. Nalaskowski, M.M., Deschermeier, C., Fanick, W., Mayr, G.W. Biochem. J. (2002) [Pubmed]
  4. The families of kinases removing the Ca2+ releasing second messenger Ins(1,4,5)P3. Nalaskowski, M.M., Mayr, G.W. Curr. Mol. Med. (2004) [Pubmed]
  5. Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate. Chang, S.C., Majerus, P.W. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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