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Chemical Compound Review

Myricetol     3,5,7-trihydroxy-2-(3,4,5...

Synonyms: Myricitin, myricetin, Cannabiscetin, Prestwick_342, CHEMBL164, ...
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Disease relevance of Myricetol


Psychiatry related information on Myricetol


High impact information on Myricetol

  • Surprisingly, LY294002 and the lead compound on which it was designed, quercetin, as well as the closely related flavonoid myricetin bind PI3K in remarkably different orientations that are related to each other by 180 degrees rotations [7].
  • Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity [8].
  • TrxR activity in the cell lysates was reduced on treatment with myricetin >50 micromol/L, which coincided with the oxidization of Trx [8].
  • The cell cycle was arrested in S phase by quercetin and an accumulation of cells in sub-G1 was observed in response to myricetin [8].
  • Thus, the anticancer activity of quercetin and myricetin may be due to inhibition of TrxR, consequently inducing cell death [8].

Chemical compound and disease context of Myricetol


Biological context of Myricetol


Anatomical context of Myricetol


Associations of Myricetol with other chemical compounds


Gene context of Myricetol


Analytical, diagnostic and therapeutic context of Myricetol


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  2. Repair of iron-induced DNA oxidation by the flavonoid myricetin in primary rat hepatocyte cultures. Abalea, V., Cillard, J., Dubos, M.P., Sergent, O., Cillard, P., Morel, I. Free Radic. Biol. Med. (1999) [Pubmed]
  3. Flavonoid intake and colorectal cancer risk in men and women. Lin, J., Zhang, S.M., Wu, K., Willett, W.C., Fuchs, C.S., Giovannucci, E. Am. J. Epidemiol. (2006) [Pubmed]
  4. Insulinomimetic effects of myricetin on lipogenesis and glucose transport in rat adipocytes but not glucose transport translocation. Ong, K.C., Khoo, H.E. Biochem. Pharmacol. (1996) [Pubmed]
  5. 3-Methylquercetin is a potent and selective inhibitor of poliovirus RNA synthesis. Castrillo, J.L., Vanden Berghe, D., Carrasco, L. Virology (1986) [Pubmed]
  6. Active oxygens generation by flavonoids. Miura, Y.H., Tomita, I., Watanabe, T., Hirayama, T., Fukui, S. Biol. Pharm. Bull. (1998) [Pubmed]
  7. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Walker, E.H., Pacold, M.E., Perisic, O., Stephens, L., Hawkins, P.T., Wymann, M.P., Williams, R.L. Mol. Cell (2000) [Pubmed]
  8. Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Lu, J., Papp, L.V., Fang, J., Rodriguez-Nieto, S., Zhivotovsky, B., Holmgren, A. Cancer Res. (2006) [Pubmed]
  9. Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine. Molina-Jiménez, M.F., Sánchez-Reus, M.I., Cascales, M., Andrés, D., Benedí, J. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  10. Phytoestrogens and prostate cancer risk. Ganry, O. Preventive medicine. (2005) [Pubmed]
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  12. Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin. van Zanden, J.J., de Mul, A., Wortelboer, H.M., Usta, M., van Bladeren, P.J., Rietjens, I.M., Cnubben, N.H. Biochem. Pharmacol. (2005) [Pubmed]
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  14. Treatment with drugs able to reduce iodine efflux significantly increases the intracellular retention time in thyroid cancer cells stably transfected with sodium iodide symporter complementary deoxyribonucleic acid. Elisei, R., Vivaldi, A., Ciampi, R., Faviana, P., Basolo, F., Santini, F., Traino, C., Pacini, F., Pinchera, A. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  15. Myricetin induces human osteoblast differentiation through bone morphogenetic protein-2/p38 mitogen-activated protein kinase pathway. Hsu, Y.L., Chang, J.K., Tsai, C.H., Chien, T.T., Kuo, P.L. Biochem. Pharmacol. (2007) [Pubmed]
  16. Effect of myricetin and other flavonoids on the liver plasma membrane Ca2+ pump. Kinetics and structure-function relationships. Thiyagarajah, P., Kuttan, S.C., Lim, S.C., Teo, T.S., Das, N.P. Biochem. Pharmacol. (1991) [Pubmed]
  17. Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase. Mayr, G.W., Windhorst, S., Hillemeier, K. J. Biol. Chem. (2005) [Pubmed]
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  19. Grape juice but not orange or grapefruit juice inhibits platelet activity in dogs and monkeys. Osman, H.E., Maalej, N., Shanmuganayagam, D., Folts, J.D. J. Nutr. (1998) [Pubmed]
  20. Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. Laughton, M.J., Halliwell, B., Evans, P.J., Hoult, J.R. Biochem. Pharmacol. (1989) [Pubmed]
  21. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Lee, K.W., Kang, N.J., Rogozin, E.A., Kim, H.G., Cho, Y.Y., Bode, A.M., Lee, H.J., Surh, Y.J., Bowden, G.T., Dong, Z. Carcinogenesis (2007) [Pubmed]
  22. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Kempuraj, D., Madhappan, B., Christodoulou, S., Boucher, W., Cao, J., Papadopoulou, N., Cetrulo, C.L., Theoharides, T.C. Br. J. Pharmacol. (2005) [Pubmed]
  23. Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease. Ono, K., Yoshiike, Y., Takashima, A., Hasegawa, K., Naiki, H., Yamada, M. J. Neurochem. (2003) [Pubmed]
  24. The modification of low density lipoprotein by the flavonoids myricetin and gossypetin. Rankin, S.M., de Whalley, C.V., Hoult, J.R., Jessup, W., Wilkins, G.M., Collard, J., Leake, D.S. Biochem. Pharmacol. (1993) [Pubmed]
  25. Intake of specific carotenoids and flavonoids and the risk of lung cancer in women in Barcelona, Spain. Garcia-Closas, R., Agudo, A., Gonzalez, C.A., Riboli, E. Nutrition and cancer. (1998) [Pubmed]
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