Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

KCTD13 - potassium channel tetramerization domain...

Homo sapiens

Synonyms: BACURD1, BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1, BTB/POZ domain-containing protein KCTD13, FKSG86, PDIP1, ...

Tomaru, T. et al., Arakaki, N. et al., He, H. et al., Zhou, J. et al.

Arakaki, Nishihama, Kohda, Owaki, Kuramoto, Abe, Kita, Suenaga, Himeda, Kuwajima, Shibata, Higuti,

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High impact information on KCTD13

It is suggested that PDIP1 provides a link between cytokine activation and DNA replication in liver as well as in other tissues [1].
PDIP1 synthesis can also be induced by tumor necrosis factor alpha and by IL-6, cytokines essential for liver regeneration after loss of hepatic tissue [1].
PDIP1alpha and -beta similarly enhanced PPARgamma-mediated transactivation in transfection assays and short interfering RNA targeting PDIP1 mRNA significantly reduced transactivation by PPARgamma [2].
PDIP1 mRNA was expressed in 3T3-L1 adipocytes and THP-1 macrophages [2].
We found that a mouse homolog of human DNA polymerase delta interacting protein 38, referred to as Mitogenin I in this paper, and mitochondrial single-stranded DNA-binding protein (mtSSB), identified as upregulated genes in the heart of mice with juvenile visceral steatosis, play a role in the regulation of mitochondrial morphology [3].

Biological context of KCTD13

The rat PDIP1 is mapped to chromosome 1q36 cM region, spans approximately 18.7 kb, and is organized into six exons [4].
No potent intrinsic activation domain was identified in either PDIP1 isoforms in mammalian one-hybrid assays, and mutation of all LXXLL motifs did not affect enhancement of PPARgamma-mediated transactivation [2].

References

A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen. He, H., Tan, C.K., Downey, K.M., So, A.G. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. Tomaru, T., Satoh, T., Yoshino, S., Ishizuka, T., Hashimoto, K., Monden, T., Yamada, M., Mori, M. Endocrinology (2006) [Pubmed]
Regulation of mitochondrial morphology and cell survival by Mitogenin I and mitochondrial single-stranded DNA binding protein. Arakaki, N., Nishihama, T., Kohda, A., Owaki, H., Kuramoto, Y., Abe, R., Kita, T., Suenaga, M., Himeda, T., Kuwajima, M., Shibata, H., Higuti, T. Biochim. Biophys. Acta (2006) [Pubmed]
Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen. Zhou, J., Hu, X., Xiong, X., Liu, X., Liu, Y., Ren, K., Jiang, T., Hu, X., Zhang, J. J. Exp. Zoolog. Part A Comp. Exp. Biol. (2005) [Pubmed]

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