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Gene Review:

SPBC17A3.06 - phosphoprotein phosphatase (predicted)

Schizosaccharomyces pombe 972h-

MacNeill, S.A. et al., Girard, F. et al., Shifrin, V.I. et al., Mukai, H. et al., Baldin, V. et al.

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Disease relevance of SPBC17A3.06

CDC25B2, a protein tyrosine phosphatase closely related to the putative CDC25B oncogene, was identified in a Burkitt lymphoma cDNA library [1].

High impact information on SPBC17A3.06

A family of proteins homologous to the cdc25 gene product of the fission yeast bear specific protein tyrosine phosphatase activity involved in the activation of the p34cdc2-cyclin B kinase [2].
Phosphorylation of protein-tyrosine phosphatase PTP-1B on identical sites suggests activation of a common signaling pathway during mitosis and stress response in mammalian cells [3].
Growth of wild-type Sp cells was inhibited by 0.5 microM phenylarsine oxide, a protein tyrosine phosphatase inhibitor, but psk1- cells were relatively resistant to this drug [4].
We show that the function of the human p34CDC2 protein in fission yeast cells is dependent upon the action of the protein tyrosine phosphatase p80cdc25, that it responds to altered levels of both the mitotic inhibitor p107wee1 and the p34cdc2-binding protein p13suc1, and is lethal in combination with the mutant B-type cyclin p56cdc13-117 [5].

References

Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control? Baldin, V., Cans, C., Superti-Furga, G., Ducommun, B. Oncogene (1997) [Pubmed]
cdc25 is a nuclear protein expressed constitutively throughout the cell cycle in nontransformed mammalian cells. Girard, F., Strausfeld, U., Cavadore, J.C., Russell, P., Fernandez, A., Lamb, N.J. J. Cell Biol. (1992) [Pubmed]
Phosphorylation of protein-tyrosine phosphatase PTP-1B on identical sites suggests activation of a common signaling pathway during mitosis and stress response in mammalian cells. Shifrin, V.I., Davis, R.J., Neel, B.G. J. Biol. Chem. (1997) [Pubmed]
Identification of Schizosaccharomyces pombe gene psk1+, encoding a novel putative serine/threonine protein kinase, whose mutation conferred resistance to phenylarsine oxide. Mukai, H., Miyahara, M., Takanaga, H., Kitagawa, M., Shibata, H., Shimakawa, M., Ono, Y. Gene (1995) [Pubmed]
Genetic analysis of human p34CDC2 function in fission yeast. MacNeill, S.A., Nurse, P. Mol. Gen. Genet. (1993) [Pubmed]

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