The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

cig1  -  cyclin Cig1

Schizosaccharomyces pombe 972h-

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on cig1


Biological context of cig1


Anatomical context of cig1


Associations of cig1 with chemical compounds

  • We have now identified two other gene products required for mitosis in A.nidulans. nimT encodes a protein similar to the fission yeast cdc25 tyrosine phosphatase and is required for the conversion of pre-MPF to MPF and nimE encodes a B-type cyclin which is a subunit of MPF [10].

Regulatory relationships of cig1


Other interactions of cig1

  • APC(ste9/srw1) is not necessary for the proteolysis of cdc13 and cig1 that occurs at the metaphase-anaphase transition but it is absolutely required for their degradation in G(1) [13].
  • Whilst p25rum1 can inhibit cig2/cdc2 activity in vitro, and may transiently inhibit this complex in vivo, cig1 is regulated independently of p25rum1 [14].
  • Deletion of cig1 and cig2/cyc17 together abolished re-replication completely and cells arrested in G1 [7].
  • The wee1- mating defect is suppressed by deletion of cig2+, which encodes a B-type cyclin that promotes the onset of S and inhibits conjugation [15].
  • We show that the function of the human p34CDC2 protein in fission yeast cells is dependent upon the action of the protein tyrosine phosphatase p80cdc25, that it responds to altered levels of both the mitotic inhibitor p107wee1 and the p34cdc2-binding protein p13suc1, and is lethal in combination with the mutant B-type cyclin p56cdc13-117 [16].


  1. Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication. Wuarin, J., Buck, V., Nurse, P., Millar, J.B. Cell (2002) [Pubmed]
  2. A fission yeast B-type cyclin functioning early in the cell cycle. Bueno, A., Richardson, H., Reed, S.I., Russell, P. Cell (1991) [Pubmed]
  3. Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast. Alfa, C.E., Ducommun, B., Beach, D., Hyams, J.S. Nature (1990) [Pubmed]
  4. rum1: a CDK inhibitor regulating G1 progression in fission yeast. Labib, K., Moreno, S. Trends Cell Biol. (1996) [Pubmed]
  5. Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle. Connolly, T., Beach, D. Mol. Cell. Biol. (1994) [Pubmed]
  6. p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle. Correa-Bordes, J., Gulli, M.P., Nurse, P. EMBO J. (1997) [Pubmed]
  7. A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. Fisher, D.L., Nurse, P. EMBO J. (1996) [Pubmed]
  8. A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast. Obara-Ishihara, T., Okayama, H. EMBO J. (1994) [Pubmed]
  9. The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe. Yamano, H., Gannon, J., Hunt, T. EMBO J. (1996) [Pubmed]
  10. An extra copy of nimEcyclinB elevates pre-MPF levels and partially suppresses mutation of nimTcdc25 in Aspergillus nidulans. O'Connell, M.J., Osmani, A.H., Morris, N.R., Osmani, S.A. EMBO J. (1992) [Pubmed]
  11. Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast. Shimada, M., Namikawa-Yamada, C., Nakanishi, M., Murakami, H. J. Biol. Chem. (2005) [Pubmed]
  12. A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes. Yamaguchi, S., Murakami, H., Okayama, H. Mol. Biol. Cell (1997) [Pubmed]
  13. APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation. Blanco, M.A., Sánchez-Díaz, A., de Prada, J.M., Moreno, S. EMBO J. (2000) [Pubmed]
  14. B-type cyclins regulate G1 progression in fission yeast in opposition to the p25rum1 cdk inhibitor. Martin-Castellanos, C., Labib, K., Moreno, S. EMBO J. (1996) [Pubmed]
  15. Roles of Wee1 and Nim1 protein kinases in regulating the switch from mitotic division to sexual development in Schizosaccharomyces pombe. Wu, L., Russell, P. Mol. Cell. Biol. (1997) [Pubmed]
  16. Genetic analysis of human p34CDC2 function in fission yeast. MacNeill, S.A., Nurse, P. Mol. Gen. Genet. (1993) [Pubmed]
WikiGenes - Universities