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Chemical Compound Review

Arzene     arsenosobenzene

Synonyms: PhAsO, Fenylarsinoxid, WLN: O-AS-R, CHEMBL477683, CHEBI:75253, ...
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Disease relevance of Oxophenylarsine


Psychiatry related information on Oxophenylarsine

  • Internalization of amyloid beta(1-42) in transfected cells was blocked by phenylarsine oxide, an inhibitor of endocytosis.We suggest that the intraneuronal accumulation of amyloid beta(1-42) in Alzheimer's disease brains occurs predominantly in neurons that express the alpha 7 receptor [6].

High impact information on Oxophenylarsine


Chemical compound and disease context of Oxophenylarsine


Biological context of Oxophenylarsine


Anatomical context of Oxophenylarsine


Associations of Oxophenylarsine with other chemical compounds


Gene context of Oxophenylarsine


Analytical, diagnostic and therapeutic context of Oxophenylarsine


  1. Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate. Schmidt, A., Rutledge, S.J., Endo, N., Opas, E.E., Tanaka, H., Wesolowski, G., Leu, C.T., Huang, Z., Ramachandaran, C., Rodan, S.B., Rodan, G.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Phenylarsine oxide blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, and induces apoptosis of acute myelogenous leukemia cells. Estrov, Z., Manna, S.K., Harris, D., Van, Q., Estey, E.H., Kantarjian, H.M., Talpaz, M., Aggarwal, B.B. Blood (1999) [Pubmed]
  3. Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide. Sandau, K.B., Zhou, J., Kietzmann, T., Brüne, B. J. Biol. Chem. (2001) [Pubmed]
  4. A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide. Hertel, C., Coulter, S.J., Perkins, J.P. J. Biol. Chem. (1985) [Pubmed]
  5. Receptor up-regulation, internalization, and interconverting receptor states. Critical components of a quantitative description of N-formyl peptide-receptor dynamics in the neutrophil. Hoffman, J.F., Linderman, J.J., Omann, G.M. J. Biol. Chem. (1996) [Pubmed]
  6. Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease. Nagele, R.G., D'Andrea, M.R., Anderson, W.J., Wang, H.Y. Neuroscience (2002) [Pubmed]
  7. Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C. Campbell, K.S., Dessing, M., Lopez-Botet, M., Cella, M., Colonna, M. J. Exp. Med. (1996) [Pubmed]
  8. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. Rodrigues, C.M., Fan, G., Ma, X., Kren, B.T., Steer, C.J. J. Clin. Invest. (1998) [Pubmed]
  9. Cytoskeleton-dependent endocytosis is required for apical type 1 angiotensin II receptor-mediated phospholipase C activation in cultured rat proximal tubule cells. Schelling, J.R., Hanson, A.S., Marzec, R., Linas, S.L. J. Clin. Invest. (1992) [Pubmed]
  10. Force transduction by Triton cytoskeletons. Sawada, Y., Sheetz, M.P. J. Cell Biol. (2002) [Pubmed]
  11. Chromaffin granule-associated phosphatidylinositol 4-kinase activity is required for stimulated secretion. Wiedemann, C., Schäfer, T., Burger, M.M. EMBO J. (1996) [Pubmed]
  12. A role for a wortmannin-sensitive phosphatidylinositol-4-kinase in the endocytosis of muscarinic cholinergic receptors. Sorensen, S.D., Linseman, D.A., McEwen, E.L., Heacock, A.M., Fisher, S.K. Mol. Pharmacol. (1998) [Pubmed]
  13. Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells. Gray, J.A., Sheffler, D.J., Bhatnagar, A., Woods, J.A., Hufeisen, S.J., Benovic, J.L., Roth, B.L. Mol. Pharmacol. (2001) [Pubmed]
  14. Multiple pathways for ligand internalization in rat hepatocytes. I: Effects of anoxia, phenylarsine oxide and monensin. Moss, A.L., Ward, W.F. J. Cell. Physiol. (1991) [Pubmed]
  15. Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: modulation of migration and invasion of human malignant glioma cells. Chintala, S.K., Kyritsis, A.P., Mohan, P.M., Mohanam, S., Sawaya, R., Gokslan, Z., Yung, W.K., Steck, P., Uhm, J.H., Aggarwal, B.B., Rao, J.S. Mol. Carcinog. (1999) [Pubmed]
  16. Reversible activation of secretory phospholipase A2 by sulfhydryl reagents. Nabemoto, M., Ohsawa, K., Nakamura, H., Hirabayashi, T., Saito, T., Okuma, Y., Nomura, Y., Murayama, T. Arch. Biochem. Biophys. (2005) [Pubmed]
  17. Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Yousefi, S., Green, D.R., Blaser, K., Simon, H.U. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  18. Complex effects of phenylarsine oxide in T cells. Induction of tyrosine phosphorylation and calcium mobilization independent of CD45 expression. Fletcher, M.C., Samelson, L.E., June, C.H. J. Biol. Chem. (1993) [Pubmed]
  19. Inhibition of phosphatidylinositol 4-kinase results in a significant reduced respiratory burst in formyl-methionyl-leucyl-phenylalanine-stimulated human neutrophils. Yue, J., Liu, J., Shen, X. J. Biol. Chem. (2001) [Pubmed]
  20. IL-3 induces down-regulation of CCR3 protein and mRNA in human eosinophils. Dulkys, Y., Kluthe, C., Buschermöhle, T., Barg, I., Knöss, S., Kapp, A., Proudfoot, A.E., Elsner, J. J. Immunol. (2001) [Pubmed]
  21. Tyrosine phosphorylation of a mitogen-activated protein kinase-like protein occurs at a late step in exocytosis. Studies with tyrosine phosphatase inhibitors and various secretagogues in rat RBL-2H3 cells. Santini, F., Beaven, M.A. J. Biol. Chem. (1993) [Pubmed]
  22. Clustered folate receptors deliver 5-methyltetrahydrofolate to cytoplasm of MA104 cells. Smart, E.J., Mineo, C., Anderson, R.G. J. Cell Biol. (1996) [Pubmed]
  23. Phenylarsine oxide-induced increase in alveolar macrophage surface receptors: evidence for fusion of internal receptor pools with the cell surface. Kaplan, J., Ward, D.M., Wiley, H.S. J. Cell Biol. (1985) [Pubmed]
  24. Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide. Garcia-Morales, P., Minami, Y., Luong, E., Klausner, R.D., Samelson, L.E. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  25. Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide. Lillig, C.H., Lönn, M.E., Enoksson, M., Fernandes, A.P., Holmgren, A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  26. Role of NAD(P)H oxidase in the tamoxifen-induced generation of reactive oxygen species and apoptosis in HepG2 human hepatoblastoma cells. Lee, Y.S., Kang, Y.S., Lee, S.H., Kim, J.A. Cell Death Differ. (2000) [Pubmed]
  27. Insulin regulation of protein phosphorylation in H4 hepatoma cells. Examination of rapid effects using two-dimensional electrophoresis. Schwartz, C.F. J. Biol. Chem. (1993) [Pubmed]
  28. Effect of phenylarsine oxide on insulin-dependent protein phosphorylation and glucose transport in 3T3-L1 adipocytes. Frost, S.C., Kohanski, R.A., Lane, M.D. J. Biol. Chem. (1987) [Pubmed]
  29. A tyrosine phosphorylation requirement for cytotoxic T lymphocyte degranulation. Anel, A., Richieri, G.V., Kleinfeld, A.M. J. Biol. Chem. (1994) [Pubmed]
  30. Membrane-associated STAT3 and PY-STAT3 in the Cytoplasm. Shah, M., Patel, K., Mukhopadhyay, S., Xu, F., Guo, G., Sehgal, P.B. J. Biol. Chem. (2006) [Pubmed]
  31. The Saccharomyces cerevisiae ACR3 gene encodes a putative membrane protein involved in arsenite transport. Wysocki, R., Bobrowicz, P., Ułaszewski, S. J. Biol. Chem. (1997) [Pubmed]
  32. Protein tyrosine kinase is expressed and regulates ROMK1 location in the cortical collecting duct. Lin, D.H., Sterling, H., Yang, B., Hebert, S.C., Giebisch, G., Wang, W.H. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  33. Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase. Shekels, L.L., Smith, A.J., Van Etten, R.L., Bernlohr, D.A. Protein Sci. (1992) [Pubmed]
  34. T-helper 2 cytokines attenuate senescent eosinophil activation by the CXCR4 ligand stromal-derived factor-1alpha (CXCL12). Dulkys, Y., Buschermöhle, T., Escher, S.E., Kapp, A., Elsner, J. Clin. Exp. Allergy (2004) [Pubmed]
  35. Phenylarsine oxide causes an insulin-dependent, GLUT4-specific degradation in rat adipocytes. Jhun, B.H., Hah, J.S., Jung, C.Y. J. Biol. Chem. (1991) [Pubmed]
  36. Evidence that tyrosine phosphorylation may increase tight junction permeability. Staddon, J.M., Herrenknecht, K., Smales, C., Rubin, L.L. J. Cell. Sci. (1995) [Pubmed]
  37. Role of protein kinase C and phosphatases in the pulmonary vasculature of neonatal piglets. Berkenbosch, J.W., Baribeau, J., Ferretti, E., Perreault, T. Crit. Care Med. (2001) [Pubmed]
  38. NAD(P)H oxidase in paraventricular nucleus contributes to the effect of angiotensin II on cardiac sympathetic afferent reflex. Zhang, Y., Yu, Y., Zhang, F., Zhong, M.K., Shi, Z., Gao, X.Y., Wang, W., Zhu, G.Q. Brain Res. (2006) [Pubmed]
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