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Gene Review

ptr3  -  ubiquitin activating enzyme E1

Schizosaccharomyces pombe 972h-

Synonyms: SPBC211.09, uba1
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High impact information on ptr3

  • Localization of a nucleoplasmin-green fluorescent protein fusion suggests that ptr2 and ptr3 have defects also in nuclear protein import [1].
  • The ptr3+ gene is essential for cell viability, and Ptr3p tagged with green fluorescent protein was localized in both the nucleus and the cytoplasm [1].
  • We cloned the ptr2+ and ptr3+ genes and found that they encode Schizosaccharomyces pombe homologues of the mammalian RCC1, a guanine nucleotide exchange factor for RAN/TC4, and the ubiquitin-activating enzyme E1 involved in ubiquitin conjugation, respectively [1].


  1. Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe. Azad, A.K., Tani, T., Shiki, N., Tsuneyoshi, S., Urushiyama, S., Ohshima, Y. Mol. Biol. Cell (1997) [Pubmed]
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