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Gene Review

hsk1  -  Dbf4(Dfp1)-dependent protein kinase Hsk1

Schizosaccharomyces pombe 972h-

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High impact information on hsk1

  • Cells with swi1, swi3, or hsk1 mutations are also defective in slowing progression through S phase in response to MMS damage [1].
  • These findings indicate a second role for hsk1 subsequent to HU arrest [2].
  • Overproduction of two of the mutant hsk1 alleles blocks initiation of DNA replication and deranges the mitotic checkpoint, a phenotype consistent with a role for Hsk1 in the early stages of initiation [3].
  • Ibp1p, a novel Cdc25-related phosphatase, suppresses Schizosaccharomyces pombe hsk1 ( cdc7) [4].


  1. Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage. Sommariva, E., Pellny, T.K., Karahan, N., Kumar, S., Huberman, J.A., Dalgaard, J.Z. Mol. Cell. Biol. (2005) [Pubmed]
  2. Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity. Snaith, H.A., Brown, G.W., Forsburg, S.L. Mol. Cell. Biol. (2000) [Pubmed]
  3. Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast. Brown, G.W., Kelly, T.J. J. Biol. Chem. (1998) [Pubmed]
  4. Ibp1p, a novel Cdc25-related phosphatase, suppresses Schizosaccharomyces pombe hsk1 ( cdc7). Snaith, H.A., Marlett, J., Forsburg, S.L. Curr. Genet. (2003) [Pubmed]
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