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SWI1  -  Swi1p

Saccharomyces cerevisiae S288c

Synonyms: ADR6, GAM3, LPA1, Regulatory protein GAM3, SWI/SNF chromatin-remodeling complex subunit SWI1, ...
 
 
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Disease relevance of SWI1

  • Other proteins containing the conserved motif include yeast SWI1, two human retinoblastoma binding proteins, and other mammalian regulatory proteins [1].
  • Expression and purification of a recombinant DNA-binding domain of ADR6 protein from Escherichia coli and its secondary structure characterization [2].
 

High impact information on SWI1

  • Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription [3].
  • Transcription of the yeast HO gene requires five genes, SWI 1, 2, 3, 4, 5 [4].
  • Here we show that the N-terminal domain of Snf5 and the second quarter of Swi1 are sites of activation domain contact [5].
  • The existence of gam3 and gam5 mutants indicates that at least two common steps control both nuclear DNA repair and the mutability of particular alleles of the mtDNA [6].
  • Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage [7].
  • Here we provide evidence that Swi1 can become a prion, [SWI+]. Swi1 aggregates in [SWI+] cells but not in nonprion cells. Cells bearing [SWI+] show a partial loss-of-function phenotype of SWI/SNF [8].
 

Biological context of SWI1

  • SWI1 and SNF5 disruptions were also synthetically lethal with ppr2Delta, suggesting that the reduced ability to remodel chromatin confers the synthetic phenotype [9].
  • SWI1, which encodes a component of the Swi-Snf complex that has chromatin remodeling activity, was identified as a gene-dosage suppressor of the ABE1-1 mutation [10].
  • Furthermore, swi1/swi1 mutant was defective in hypha-specific gene expression and avirulent in a mouse model of systemic infection [11].
  • The lack of sequence specificity shown by the SWI1 ARID domain stands in contrast to the other characterized ARID domains, which recognize specific AT-rich sequences [12].
  • Sequence analysis and substitution mutagenesis reveals that the weak DNA-binding affinity of the SWI1 ARID is an intrinsic feature of its sequence, arising from specific variations in the major groove interaction site [13].
 

Associations of SWI1 with chemical compounds

  • Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors [14].
  • Expression of C. albicans SWI1 in S. cerevisiae partially complemented the growth defect of a swi1 mutant in the utilization of glycerol [11].
  • We have cloned the Hansenula polymorpha SWI1 and SNF2 genes by functional complementation of mutants that are defective in methanol utilisation [15].
  • Analysis of the phenotypes of constructed H. polymorpha SWI1 and SNF2 disruption strains indicated that these genes are not necessary for growth of cells on glucose, sucrose, or various organic nitrogen sources which involve the activity of peroxisomal oxidases [15].
  • RESULTS: We apply this method to Saccharomyces cerevisiae microarray datasets on the transcriptional response to ethanol shock, to SNF2 and SWI1 deletion in rich and minimal media, and to wild-type and zap1 expression in media with high, medium, and low levels of zinc [16].
 

Physical interactions of SWI1

 

Other interactions of SWI1

  • We show here that transcription of HO in swi1 sin1 cells efficiently utilizes the normal start site [18].
  • This suggests that SIN3 and SWI1 may play opposite regulatory roles in controlling expression of many yeast genes [19].
  • The identification and characterization of ADR6, a gene required for sporulation and for expression of the alcohol dehydrogenase II isozyme from Saccharomyces cerevisiae [20].
  • The ADR6 locus was unlinked to the ADR1 gene which encodes another trans-acting element required for ADH2 expression [20].
  • These mutants define five complementation and linkage groups, SWI 1 to SWI 5 [21].
 

Analytical, diagnostic and therapeutic context of SWI1

  • We have performed whole-genome expression analysis, using DNA microarrays, to study mutants deleted for a gene encoding one conserved (Snf2) or one unconserved (Swi1) Snf/Swi component [22].
  • With Ni-chelating column and high-performance liquid chromatography (HPLC), This recombinant protein (RDB-ADR6) could reach more than 95% purity [2].

References

  1. Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteins. Gregory, S.L., Kortschak, R.D., Kalionis, B., Saint, R. Mol. Cell. Biol. (1996) [Pubmed]
  2. Expression and purification of a recombinant DNA-binding domain of ADR6 protein from Escherichia coli and its secondary structure characterization. Tu, X., Xiao, Y., Zeng, W., Shi, Y. Biochim. Biophys. Acta (2000) [Pubmed]
  3. Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription. Peterson, C.L., Herskowitz, I. Cell (1992) [Pubmed]
  4. Activation of the yeast HO gene by release from multiple negative controls. Sternberg, P.W., Stern, M.J., Clark, I., Herskowitz, I. Cell (1987) [Pubmed]
  5. Targeting activity is required for SWI/SNF function in vivo and is accomplished through two partially redundant activator-interaction domains. Prochasson, P., Neely, K.E., Hassan, A.H., Li, B., Workman, J.L. Mol. Cell (2003) [Pubmed]
  6. Genetic control of enhanced mutability of mitochondrial DNA and gamma-ray sensitivity in Saccharomyces cerevisiae. Foury, F., Goffeau, A. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  7. Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage. Sommariva, E., Pellny, T.K., Karahan, N., Kumar, S., Huberman, J.A., Dalgaard, J.Z. Mol. Cell. Biol. (2005) [Pubmed]
  8. Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae. Du, Z., Park, K.W., Yu, H., Fan, Q., Li, L. Nat. Genet. (2008) [Pubmed]
  9. Genetic interactions between TFIIS and the Swi-Snf chromatin-remodeling complex. Davie, J.K., Kane, C.M. Mol. Cell. Biol. (2000) [Pubmed]
  10. Gal11 is a general activator of basal transcription, whose activity is regulated by the general repressor Sin4 in yeast. Mizuno, T., Harashima, S. Mol. Genet. Genomics (2003) [Pubmed]
  11. The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans. Mao, X., Cao, F., Nie, X., Liu, H., Chen, J. FEBS Lett. (2006) [Pubmed]
  12. Structure and DNA-binding sites of the SWI1 AT-rich interaction domain (ARID) suggest determinants for sequence-specific DNA recognition. Kim, S., Zhang, Z., Upchurch, S., Isern, N., Chen, Y. J. Biol. Chem. (2004) [Pubmed]
  13. The DNA-binding properties of the ARID-containing subunits of yeast and mammalian SWI/SNF complexes. Wilsker, D., Patsialou, A., Zumbrun, S.D., Kim, S., Chen, Y., Dallas, P.B., Moran, E. Nucleic Acids Res. (2004) [Pubmed]
  14. Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors. Yoshinaga, S.K., Peterson, C.L., Herskowitz, I., Yamamoto, K.R. Science (1992) [Pubmed]
  15. Hansenula polymorpha Swi1p and Snf2p are essential for methanol utilisation. Ozimek, P., Lahtchev, K., Kiel, J.A., Veenhuis, M., van der Klei, I.J. FEMS Yeast Res. (2004) [Pubmed]
  16. Bayesian analysis of gene expression levels: statistical quantification of relative mRNA level across multiple strains or treatments. Townsend, J.P., Hartl, D.L. Genome Biol. (2002) [Pubmed]
  17. Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex. Matsumoto, S., Ogino, K., Noguchi, E., Russell, P., Masai, H. J. Biol. Chem. (2005) [Pubmed]
  18. A negative regulator of HO transcription, SIN1 (SPT2), is a nonspecific DNA-binding protein related to HMG1. Kruger, W., Herskowitz, I. Mol. Cell. Biol. (1991) [Pubmed]
  19. Genetic interactions between SIN3 mutations and the Saccharomyces cerevisiae transcriptional activators encoded by MCM1, STE12, and SWI1. Wang, H., Reynolds-Hager, L., Stillman, D.J. Mol. Gen. Genet. (1994) [Pubmed]
  20. The identification and characterization of ADR6, a gene required for sporulation and for expression of the alcohol dehydrogenase II isozyme from Saccharomyces cerevisiae. Taguchi, A.K., Young, E.T. Genetics (1987) [Pubmed]
  21. Five SWI genes are required for expression of the HO gene in yeast. Stern, M., Jensen, R., Herskowitz, I. J. Mol. Biol. (1984) [Pubmed]
  22. Whole-genome expression analysis of snf/swi mutants of Saccharomyces cerevisiae. Sudarsanam, P., Iyer, V.R., Brown, P.O., Winston, F. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
 
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