High impact information on cdc7

• In Schizosaccharomyces pombe, the sid genes (cdc7, cdc11, cdc14, spg1, sid1, sid2 and sid4) define a signaling pathway that regulates septation and cytokinesis [1].
• In the absence of cdc7 function, spore germination, DNA synthesis and mitosis are unaffected, but cells are unable to initiate formation of the division septum [2].
• Mutation of the Schizosaccharomyces pombe cdc7 gene prevents formation of the division septum and cytokinesis [2].
• We have cloned the cdc7 gene and show that it encodes a protein kinase which is essential for cell division [2].
• Mutations in the S. pombe early septation mutants cdc7, cdc11, cdc14 and cdc15 lead to the formation of elongated, multinucleate cells, as a result of S phase and mitosis continuing in the absence of cytokinesis [3].

Biological context of cdc7

• We demonstrate that mitotic hyperphosphorylation of cdc11p requires the activity of cdc7p and that its dephosphorylation at the end of mitosis requires PP2A-par1p [4].
• Double staining indicates that this is the opposite pole to that which retains cdc7p in late anaphase [5].

Associations of cdc7 with chemical compounds

• However two other mutants, cdc 4 and cdc 7, show a higher galactomannan content and a lower alpha-glucan content [6].

Other interactions of cdc7

• Ibp1p, a novel Cdc25-related phosphatase, suppresses Schizosaccharomyces pombe hsk1 ( cdc7) [7].
• In this work, we demonstrate that attenuation of the protein kinase cdc7p can rescue the lethality of a null allele of cdc16 [8].

Analytical, diagnostic and therapeutic context of cdc7

• Immunofluorescence studies have shown that cdc7p is located on both spindle pole bodies early in mitosis, but only on one during the later stages of anaphase [5].

References