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Gene Review

cdc7  -  serine/threonine protein kinase Cdc7

Schizosaccharomyces pombe 972h-

Synonyms: its10, pld1
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High impact information on cdc7


Biological context of cdc7

  • We demonstrate that mitotic hyperphosphorylation of cdc11p requires the activity of cdc7p and that its dephosphorylation at the end of mitosis requires PP2A-par1p [4].
  • Double staining indicates that this is the opposite pole to that which retains cdc7p in late anaphase [5].

Associations of cdc7 with chemical compounds


Other interactions of cdc7

  • Ibp1p, a novel Cdc25-related phosphatase, suppresses Schizosaccharomyces pombe hsk1 ( cdc7) [7].
  • In this work, we demonstrate that attenuation of the protein kinase cdc7p can rescue the lethality of a null allele of cdc16 [8].

Analytical, diagnostic and therapeutic context of cdc7


  1. The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast. Guertin, D.A., Chang, L., Irshad, F., Gould, K.L., McCollum, D. EMBO J. (2000) [Pubmed]
  2. The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast. Fankhauser, C., Simanis, V. EMBO J. (1994) [Pubmed]
  3. The S. pombe cdc16 gene is required both for maintenance of p34cdc2 kinase activity and regulation of septum formation: a link between mitosis and cytokinesis? Fankhauser, C., Marks, J., Reymond, A., Simanis, V. EMBO J. (1993) [Pubmed]
  4. Mitotic hyperphosphorylation of the fission yeast SIN scaffold protein cdc11p is regulated by the protein kinase cdc7p. Krapp, A., Cano, E., Simanis, V. Curr. Biol. (2003) [Pubmed]
  5. Asymmetry of the spindle pole bodies and spg1p GAP segregation during mitosis in fission yeast. Cerutti, L., Simanis, V. J. Cell. Sci. (1999) [Pubmed]
  6. Ultrastructure and cell wall composition in cell division cycle mutants of Schizosaccharomyces pombe deficient in septum formation. Mateos, P., Domínguez, A. Antonie Van Leeuwenhoek (1991) [Pubmed]
  7. Ibp1p, a novel Cdc25-related phosphatase, suppresses Schizosaccharomyces pombe hsk1 ( cdc7). Snaith, H.A., Marlett, J., Forsburg, S.L. Curr. Genet. (2003) [Pubmed]
  8. Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes. Fournier, N., Cerutti, L., Beltraminelli, N., Salimova, E., Simanis, V. Arch. Microbiol. (2001) [Pubmed]
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