Gene Review:
CDC7 - Cdc7p
Saccharomyces cerevisiae S288c
Synonyms:
Cell division control protein 7, D2855, LSD6, OAF2, SAS1, ...
- Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. Weinreich, M., Stillman, B. EMBO J. (1999)
- Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle. Yoon, H.J., Loo, S., Campbell, J.L. Mol. Biol. Cell (1993)
- Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Dowell, S.J., Romanowski, P., Diffley, J.F. Science (1994)
- A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication. Pasero, P., Duncker, B.P., Schwob, E., Gasser, S.M. Genes Dev. (1999)
- The Cdc7 protein kinase is required for origin firing during S phase. Bousset, K., Diffley, J.F. Genes Dev. (1998)
- Cdc7 is required throughout the yeast S phase to activate replication origins. Donaldson, A.D., Fangman, W.L., Brewer, B.J. Genes Dev. (1998)
- CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication. Owens, J.C., Detweiler, C.S., Li, J.J. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents. Siede, W., Friedberg, A.S., Dianova, I., Friedberg, E.C. Genetics (1994)
- A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines. Hess, G.F., Drong, R.F., Weiland, K.L., Slightom, J.L., Sclafani, R.A., Hollingsworth, R.E. Gene (1998)
- Cell cycle inhibition of yeast spheroplasts. Murakami, S., Livingston, D.M. Mol. Gen. Genet. (1982)
- Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development. Kim, J.M., Yamada, M., Masai, H. Mutat. Res. (2003)
- DNA metabolism gene CDC7 from yeast encodes a serine (threonine) protein kinase. Hollingsworth, R.E., Sclafani, R.A. Proc. Natl. Acad. Sci. U.S.A. (1990)
- A fission yeast gene, him1(+)/dfp1(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage. Takeda, T., Ogino, K., Matsui, E., Cho, M.K., Kumagai, H., Miyake, T., Arai, K., Masai, H. Mol. Cell. Biol. (1999)
- A generic time-resolved fluorescence assay for serine/threonine kinase activity: application to Cdc7/Dbf4. Xu, K., Stern, A.S., Levin, W., Chua, A., Vassilev, L.T. J. Biochem. Mol. Biol. (2003)
- Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex. Matsumoto, S., Ogino, K., Noguchi, E., Russell, P., Masai, H. J. Biol. Chem. (2005)
- Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle. Hengstschläger, M., Braun, K., Soucek, T., Miloloza, A., Hengstschläger-Ottnad, E. Mutat. Res. (1999)
- The CDC7 protein of Saccharomyces cerevisiae is a phosphoprotein that contains protein kinase activity. Yoon, H.J., Campbell, J.L. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Genetic interactions between CDC7 and CDC28: growth inhibition of cdc28-1N by Cdc7 point mutants. Ohtoshi, A., Arai, K., Masai, H. Genes Cells (1996)
- Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition. Kitada, K., Johnston, L.H., Sugino, T., Sugino, A. Genetics (1992)
- Cyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts. Duncker, B.P., Pasero, P., Braguglia, D., Heun, P., Weinreich, M., Gasser, S.M. Mol. Cell. Biol. (1999)
- Regulation of CDC9, the Saccharomyces cerevisiae gene that encodes DNA ligase. Peterson, T.A., Prakash, L., Prakash, S., Osley, M.A., Reed, S.I. Mol. Cell. Biol. (1985)
- CDC7/DBF4 functions in the translesion synthesis branch of the RAD6 epistasis group in Saccharomyces cerevisiae. Pessoa-Brandão, L., Sclafani, R.A. Genetics (2004)
- Characterization of an essential Orc2p-associated factor that plays a role in DNA replication. Hardy, C.F. Mol. Cell. Biol. (1996)
- hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication. Masai, H., Miyake, T., Arai, K. EMBO J. (1995)
- Cloning of the CDC7 gene of Saccharomyces cerevisiae in association with centromeric DNA. Meddle, C.C., Kumar, P., Ham, J., Hughes, D.A., Johnston, I.R. Gene (1985)
- SEPH, a Cdc7p orthologue from Aspergillus nidulans, functions upstream of actin ring formation during cytokinesis. Bruno, K.S., Morrell, J.L., Hamer, J.E., Staiger, C.J. Mol. Microbiol. (2001)