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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cdc42  -  Rho family GTPase Cdc42

Schizosaccharomyces pombe 972h-

 
 
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High impact information on cdc42

  • Gene disruption of pak1+ establishes that, like cdc42+, pak1+ function is required for cell viability [1].
  • The cdc42 null phenotype is an arrest as small, round, dense cells [2].
  • While overexpression of either shk2 or cdc42 alone does not impair growth of wild type fission yeast cells, cooverexpression of the two genes is toxic and leads to highly aberrant cell morphology, providing evidence for functional interaction between Cdc42 and Shk2 proteins in vivo [3].

References

  1. Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. Ottilie, S., Miller, P.J., Johnson, D.I., Creasy, C.L., Sells, M.A., Bagrodia, S., Forsburg, S.L., Chernoff, J. EMBO J. (1995) [Pubmed]
  2. Cdc42p GTPase is involved in controlling polarized cell growth in Schizosaccharomyces pombe. Miller, P.J., Johnson, D.I. Mol. Cell. Biol. (1994) [Pubmed]
  3. Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast. Yang, P., Kansra, S., Pimental, R.A., Gilbreth, M., Marcus, S. J. Biol. Chem. (1998) [Pubmed]
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