Gene Review:
Cdc42 - cell division cycle 42
Rattus norvegicus
Synonyms:
Cell division control protein 42 homolog
- Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression. Hahn, A., Barth, H., Kress, M., Mertens, P.R., Goppelt-Struebe, M. Biochem. J. (2002)
- Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy. Chockalingam, P.S., Cholera, R., Oak, S.A., Zheng, Y., Jarrett, H.W., Thomason, D.B. Am. J. Physiol., Cell Physiol. (2002)
- PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nishimura, T., Yamaguchi, T., Kato, K., Yoshizawa, M., Nabeshima, Y., Ohno, S., Hoshino, M., Kaibuchi, K. Nat. Cell Biol. (2005)
- Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. Rohatgi, R., Ho, H.Y., Kirschner, M.W. J. Cell Biol. (2000)
- An essential role for Rac/Cdc42 GTPases in cerebellar granule neuron survival. Linseman, D.A., Laessig, T., Meintzer, M.K., McClure, M., Barth, H., Aktories, K., Heidenreich, K.A. J. Biol. Chem. (2001)
- Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Etienne-Manneville, S., Hall, A. Cell (2001)
- The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Rohatgi, R., Ma, L., Miki, H., Lopez, M., Kirchhausen, T., Takenawa, T., Kirschner, M.W. Cell (1999)
- Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Etienne-Manneville, S., Hall, A. Nature (2003)
- The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Auer, K.L., Contessa, J., Brenz-Verca, S., Pirola, L., Rusconi, S., Cooper, G., Abo, A., Wymann, M.P., Davis, R.J., Birrer, M., Dent, P. Mol. Biol. Cell (1998)
- Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic beta cells. Kowluru, A., Li, G., Rabaglia, M.E., Segu, V.B., Hofmann, F., Aktories, K., Metz, S.A. Biochem. Pharmacol. (1997)
- Hypotonicity induces membrane protrusions and actin remodeling via activation of small GTPases Rac and Cdc42 in Rat-1 fibroblasts. Carton, I., Hermans, D., Eggermont, J. Am. J. Physiol., Cell Physiol. (2003)
- ADP-ribosylating and glucosylating toxins as tools to study secretion in RBL cells. Prepens, U., Just, I., Hofmann, F., Aktories, K. Adv. Exp. Med. Biol. (1997)
- Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments. Izumi, G., Sakisaka, T., Baba, T., Tanaka, S., Morimoto, K., Takai, Y. J. Cell Biol. (2004)
- Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells. Aoki, K., Nakamura, T., Matsuda, M. J. Biol. Chem. (2004)
- Small GTPase Rin induces neurite outgrowth through Rac/Cdc42 and calmodulin in PC12 cells. Hoshino, M., Nakamura, S. J. Cell Biol. (2003)
- Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles. Chen, J.L., Fucini, R.V., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Stamnes, M. J. Cell Biol. (2005)
- Targeting of the myosin-I myr 3 to intercellular adherens type junctions induced by dominant active Cdc42 in HeLa cells. Stöffler, H.E., Honnert, U., Bauer, C.A., Höfer, D., Schwarz, H., Müller, R.T., Drenckhahn, D., Bähler, M. J. Cell. Sci. (1998)
- Serotonin-induced regulation of the actin network for learning-related synaptic growth requires Cdc42, N-WASP, and PAK in Aplysia sensory neurons. Udo, H., Jin, I., Kim, J.H., Li, H.L., Youn, T., Hawkins, R.D., Kandel, E.R., Bailey, C.H. Neuron (2005)
- PAK promotes morphological changes by acting upstream of Rac. Obermeier, A., Ahmed, S., Manser, E., Yen, S.C., Hall, C., Lim, L. EMBO J. (1998)
- Binding of Cdc42 to phospholipase D1 is important in neurite outgrowth of neural stem cells. Yoon, M.S., Cho, C.H., Lee, K.S., Han, J.S. Biochem. Biophys. Res. Commun. (2006)
- Delineation of the Cdc42/Rac-binding domain of p21-activated kinase. Thompson, G., Owen, D., Chalk, P.A., Lowe, P.N. Biochemistry (1998)
- Conformational switch and role of phosphorylation in PAK activation. Buchwald, G., Hostinova, E., Rudolph, M.G., Kraemer, A., Sickmann, A., Meyer, H.E., Scheffzek, K., Wittinghofer, A. Mol. Cell. Biol. (2001)
- Essential role of neural Wiskott-Aldrich syndrome protein in neurite extension in PC12 cells and rat hippocampal primary culture cells. Banzai, Y., Miki, H., Yamaguchi, H., Takenawa, T. J. Biol. Chem. (2000)
- PACAP activates Rac1 and synergizes with NGF to activate ERK1/2, thereby inducing neurite outgrowth in PC12 cells. Sakai, Y., Hashimoto, H., Shintani, N., Katoh, H., Negishi, M., Kawaguchi, C., Kasai, A., Baba, A. Brain Res. Mol. Brain Res. (2004)
- Integrin-mediated signals regulated by members of the rho family of GTPases. Clark, E.A., King, W.G., Brugge, J.S., Symons, M., Hynes, R.O. J. Cell Biol. (1998)
- Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. Manser, E., Chong, C., Zhao, Z.S., Leung, T., Michael, G., Hall, C., Lim, L. J. Biol. Chem. (1995)
- Fibroblast transformation by Fps/Fes tyrosine kinases requires Ras, Rac, and Cdc42 and induces extracellular signal-regulated and c-Jun N-terminal kinase activation. Li, J., Smithgall, T.E. J. Biol. Chem. (1998)
- Molecular cloning and sequencing of rat Cdc42 GTPase cDNA. Han, J.S., Kim, J.H., Kim, J.G., Park, J.B., Noh, D.Y., Lee, K.H. Exp. Mol. Med. (2000)
- Modulation of Rho and cytoskeletal protein attachment to membranes by a prenylcysteine analog. Desrosiers, R.R., Gauthier, F., Lanthier, J., Béliveau, R. J. Biol. Chem. (2000)
- Inhibition of Fc epsilon-RI-mediated activation of rat basophilic leukemia cells by Clostridium difficile toxin B (monoglucosyltransferase). Prepens, U., Just, I., von Eichel-Streiber, C., Aktories, K. J. Biol. Chem. (1996)