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Gene Review

SLC41A1  -  solute carrier family 41 (magnesium...

Homo sapiens

Synonyms: MgtE, Solute carrier family 41 member 1
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Disease relevance of SLC41A1


High impact information on SLC41A1

  • The gene encoding SLC41A1 is found on chromosome 1 (1q31-32) and the protein coding sequence is found on 10 exons [2].
  • Mouse SLC41A1 was cloned from MDCT cells, expressed in Xenopus laevis oocytes, and studied with two-electrode voltage-clamp studies [1].
  • These studies suggest that SLC41A1 is a regulated Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells [1].
  • Structure-function analysis of SLC41A1 upon overexpression in TRPM7-deficient DT40 cells suggested that it has the same plasma membrane orientation as the bacterial MgtE transporter and that it's N-terminal cytoplasmic domain is involved in regulation of Mg2+ transport [3].

Anatomical context of SLC41A1

  • When expressed in oocytes, SLC41A1 mediates saturable Mg2+ uptake with a Michaelis constant of 0.67 mM [1].



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