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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLC41A1  -  solute carrier family 41 (magnesium...

Homo sapiens

Synonyms: MgtE, Solute carrier family 41 member 1
 
 
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Disease relevance of SLC41A1

 

High impact information on SLC41A1

  • The gene encoding SLC41A1 is found on chromosome 1 (1q31-32) and the protein coding sequence is found on 10 exons [2].
  • Mouse SLC41A1 was cloned from MDCT cells, expressed in Xenopus laevis oocytes, and studied with two-electrode voltage-clamp studies [1].
  • These studies suggest that SLC41A1 is a regulated Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells [1].
  • Structure-function analysis of SLC41A1 upon overexpression in TRPM7-deficient DT40 cells suggested that it has the same plasma membrane orientation as the bacterial MgtE transporter and that it's N-terminal cytoplasmic domain is involved in regulation of Mg2+ transport [3].
 

Anatomical context of SLC41A1

  • When expressed in oocytes, SLC41A1 mediates saturable Mg2+ uptake with a Michaelis constant of 0.67 mM [1].

 

References

  1. Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters. Goytain, A., Quamme, G.A. Physiol. Genomics (2005) [Pubmed]
  2. The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. Wabakken, T., Rian, E., Kveine, M., Aasheim, H.C. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  3. SLC41A1 Mg(2+) transport is regulated via Mg(2+)-dependent endosomal recycling through its N-terminal cytoplasmic domain. Mandt, T., Song, Y., Scharenberg, A.M., Sahni, J. Biochem. J. (2011) [Pubmed]
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