Disease relevance of Magnesium Deficiency

• CONCLUSIONS: Malnutrition may not itself give rise to glucose intolerance, and serum magnesium deficiency seems to be a consequence rather than a cause of diabetes mellitus [1].
• It is speculated that thorium excess in conjunction with magnesium deficiency may play a role in the causation of tropical endomyocardial fibrosis [2].
• To determine the relevance of circulating 1,25-dihydroxycholecalciferol [1,25(OH)2D3] to the pathogenesis of hypocalcemia during magnesium deficiency, growing chicks were pair fed control or Mg-deficient diets with or without 1,25(OH)2D3 supplementation [3].
• Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats [4].
• Hypocalcemic crisis in alcoholic fatty liver: transient hypoparathyroidism due to magnesium deficiency [5].

Psychiatry related information on Magnesium Deficiency

• After thoroughly researching the literature, I hypothesize that magnesium deficiency may be the central precipitating event and common pathway for the subsequent biochemical effects on substance P, kynurenine, NMDA receptors, and vitamin B6 that may result in the symptomatology of Tourette's syndrome and several reported comorbid conditions [6].

High impact information on Magnesium Deficiency

• Evidence for skeletal resistance to parathyroid hormone in magnesium deficiency. Studies in isolated perfused bone [7].
• We conclude that cisplatin can induce a renal tubular defect in magnesium conservation and serious clinical syndromes of magnesium deficiency [8].
• Thus, the paradoxical block of PTH release under magnesium deficiency seems to be mediated through a novel mechanism involving an increase in the activity of G alpha subunits of heterotrimeric G-proteins [9].
• Magnesium deficiency in IDDM related to level of glycosylated hemoglobin [10].
• Relation between severity of magnesium deficiency and frequency of anginal attacks in men with variant angina [11].

Chemical compound and disease context of Magnesium Deficiency

• The effect of magnesium deficiency on glucose disposal, glucose-stimulated insulin secretion and insulin action on skeletal muscle was investigated in rats which were fed a low magnesium-containing diet for 4 days [12].
• These data show that serum 1,25-(OH)2D concentrations are frequently low in patients with magnesium deficiency and may remain low even after 5-13 days of parenteral magnesium administration [13].
• Low serum concentrations of 1,25-dihydroxyvitamin D in human magnesium deficiency [13].
• It is possible that the reduced magnesium content of the high-fructose commercial diet used in some studies may play a role in these abnormalities because it is known that magnesium deficiency can produce insulin insensitivity and increased angiotensin II action in humans [14].
• Similarly, angiotensin II-induced plasma aldosterone concentration increased after magnesium deficiency [15].

Biological context of Magnesium Deficiency

• Little attention has been paid to interactions between circulating levels of calcium, PTH, and 1,25-dihydroxycholecalciferol [1,25(OH)2D] and bone mineral density in primary renal magnesium deficiency [16].
• Renin immunochemistry, sodium excretion and relative heart weight in cyclosporine- or alimentary-induced magnesium deficiency in rats [17].
• Digoxin reduces tubular magnesium reabsorption, and in patients with congestive heart failure this interaction may be cumulative with other causes of magnesium deficiency (diuretics, diet, poor intestinal absorption) [18].

Anatomical context of Magnesium Deficiency

• It is suggested that magnesium deficiency may result in defective cyclic AMP generation in the parathyroid glands and in the PTH target organs [19].
• OBJECTIVE: To investigate the effects of enrofloxacin and magnesium deficiency on explants of equine articular cartilage [20].
• To determine the contribution of the juxtamedullary loop of Henle to magnesium reabsorption during magnesium deficiency, we performed two-phase micropuncture studies of end-descending limbs in a group of magnesium-deficient rats (n = 7) and in a pair-fed control group (n = 8) given MgCl2 in their drinking water [21].
• The effects of magnesium deficiency on uptake and metabolism of low density lipoprotein (LDL) were investigated using human arterial endothelial cells cultured in media containing various concentrations of magnesium (100-1000 microM) and a high concentration of LDL (2 mg LDL cholesterol/ml) labelled with [3H]cholesteryl linoleate [22].
• Effect of dietary magnesium deficiency with/without cholesterol supplementation on phospholipid content in liver, plasma and erythrocytes of rabbits [23].

Gene context of Magnesium Deficiency

• Plasma levels of the inflammatory cytokines tumour necrosis factor (TNF) and interleukin-6 (IL-6) are increased in NEC and in magnesium deficiency; these experimentally produce shock and tissue injury, especially of the intestine [24].
• The first week of dietary magnesium deficiency in rodent models is characterized by the induction of raised levels of neuropeptides (substance P [SP] and calcitonin gene related peptide [CGRP]), followed shortly thereafter by inflammatory cytokine release [25].
• Thus, hypocalcemic crisis in this patient appeared to result from transient hypoparathyroidism induced by magnesium deficiency [5].
• Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin [26].
• Extracellular magnesium deficiency induces contraction of arterial muscle: role of PI3-kinases and MAPK signaling pathways [27].

Analytical, diagnostic and therapeutic context of Magnesium Deficiency

• Urinary thromboxane concentration measured by radioimmunoassay increased after magnesium deficiency [15].
• Effects of partial and total colectomy on mineral and acid-base homoeostasis in the rat: magnesium deficiency, hyperphosphaturia and osteopathy, in the presence of high serum 1,25-dihydroxyvitamin D but normal parathyroid hormone [28].
• Magnesium deficiency after renal transplantation and cyclosporine treatment despite normal serum-magnesium detected by a modified magnesium-loading-test [29].

References