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Gene Review:

CT47A11 - cancer/testis antigen family 47, member A11

Homo sapiens

Synonyms: CT47.11

Chen, Y.T. et al., Kwiatkowski, D.J. et al.

Chen, Iseli, Venditti, Old, Simpson, Jongeneel,

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Disease relevance of RP6-166C19.11

Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome [1].
Among the tumor specimens tested, CT47 expression was found in approximately 15% of lung cancer and esophageal cancer specimens, but not in colorectal cancer or breast cancer [1].

High impact information on RP6-166C19.11

Amino acid sequence analyses place CT17 at the NH2 terminus of gelsolin and CT47 at the carboxyl-terminal two-thirds of gelsolin [2].
The expression of these genes in normal tissues and various tumor cell lines and specimens was evaluated by qualitative and quantitative RT-PCR, and a novel CT gene family with at least 13 copies was identified on Xq24, designated as CT47. mRNA expression of CT47 was found mainly in the testes, with weak expression in the placenta [1].
The putative CT47 protein consists of 288 amino acid residues, with a C-terminus rich in alanine and glutamic acid [1].

Anatomical context of RP6-166C19.11

Brain tissue was the only positive somatic tissue tested, with an estimated CT47 transcript level 0.09% of that found in testis [1].

Analytical, diagnostic and therapeutic context of RP6-166C19.11

Circular dichroism measurements show that Ca2+ induces an increase in the alpha-helical content of CT47 [2].

References

Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. Chen, Y.T., Iseli, C., Venditti, C.A., Old, L.J., Simpson, A.J., Jongeneel, C.V. Genes Chromosomes Cancer (2006) [Pubmed]
Isolation and properties of two actin-binding domains in gelsolin. Kwiatkowski, D.J., Janmey, P.A., Mole, J.E., Yin, H.L. J. Biol. Chem. (1985) [Pubmed]

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