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Gene Review

CT47A11  -  cancer/testis antigen family 47, member A11

Homo sapiens

Synonyms: CT47.11
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Disease relevance of RP6-166C19.11


High impact information on RP6-166C19.11

  • Amino acid sequence analyses place CT17 at the NH2 terminus of gelsolin and CT47 at the carboxyl-terminal two-thirds of gelsolin [2].
  • The expression of these genes in normal tissues and various tumor cell lines and specimens was evaluated by qualitative and quantitative RT-PCR, and a novel CT gene family with at least 13 copies was identified on Xq24, designated as CT47. mRNA expression of CT47 was found mainly in the testes, with weak expression in the placenta [1].
  • The putative CT47 protein consists of 288 amino acid residues, with a C-terminus rich in alanine and glutamic acid [1].

Anatomical context of RP6-166C19.11

  • Brain tissue was the only positive somatic tissue tested, with an estimated CT47 transcript level 0.09% of that found in testis [1].

Analytical, diagnostic and therapeutic context of RP6-166C19.11

  • Circular dichroism measurements show that Ca2+ induces an increase in the alpha-helical content of CT47 [2].


  1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. Chen, Y.T., Iseli, C., Venditti, C.A., Old, L.J., Simpson, A.J., Jongeneel, C.V. Genes Chromosomes Cancer (2006) [Pubmed]
  2. Isolation and properties of two actin-binding domains in gelsolin. Kwiatkowski, D.J., Janmey, P.A., Mole, J.E., Yin, H.L. J. Biol. Chem. (1985) [Pubmed]
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