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Gene Review:

BCL6B - B-cell CLL/lymphoma 6, member B

Homo sapiens

Synonyms: B-cell CLL/lymphoma 6 member B protein, BAZF, Bcl6-associated zinc finger protein, ZBTB28, ZNF62, ...

Sakashita, C. et al., Okabe, S. et al., Fitzgibbon, J. et al.

Fitzgibbon, Neat, Jones, Foot, Lister, Gupta,

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Disease relevance of BCL6B

BAZF mRNA was expressed in some immature B cell lines and erythroleukemia cell lines [1].

High impact information on BCL6B

The predicted amino acid sequence of BAZF indicated that the BTB/POZ domain and the five repeats of the Krüppel-like zinc finger motif are located in the NH2-terminal region and the COOH-terminal region, respectively [2].
These expression patterns of BAZF mRNA suggest that BAZF may regulate differentiation in stages or lineages that are different from those regulated by BCL6 [1].
Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene [1].
The predicted amino acid sequence was 91% identical to that of murine BAZF [1].
Fluorescence in situ hybridization analysis revealed that the human BAZF gene is located on chromosome 17p13 [1].

Biological context of BCL6B

Assignment of B-cell lymphoma 6, member B (zinc finger protein) gene (BCL6B) to human chromosome 17p13.1 by in situ hybridization [3].

References

Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene. Sakashita, C., Fukuda, T., Okabe, S., Kobayashi, H., Hirosawa, S., Tokuhisa, T., Miyasaka, N., Miura, O., Miki, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. Okabe, S., Fukuda, T., Ishibashi, K., Kojima, S., Okada, S., Hatano, M., Ebara, M., Saisho, H., Tokuhisa, T. Mol. Cell. Biol. (1998) [Pubmed]
Assignment of B-cell lymphoma 6, member B (zinc finger protein) gene (BCL6B) to human chromosome 17p13.1 by in situ hybridization. Fitzgibbon, J., Neat, M.J., Jones, L., Foot, N., Lister, T.A., Gupta, R.K. Cytogenet. Cell Genet. (2000) [Pubmed]

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