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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cna  -  collagen adhesin

Clostridium perfringens str. 13

 
 
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Disease relevance of cna

  • The finding that CpCna binds collagen and that the cna gene is associated with the consensus cpb2 allele implicates CpCna as a potential virulence factor in porcine enteritis caused by C. perfringens [1].
 

High impact information on cna

  • In C. perfringens strain 13, the consensus cpb2 allele is found on the plasmid pCP13, which also carries cna, encoding a putative collagen binding protein, CpCna [1].
 

Analytical, diagnostic and therapeutic context of cna

  • Genomic DNA from C. perfringens isolated from a variety of host species were subjected to PCR to determine the prevalence of cna in these strains and correlate its carriage with the presence and type of cpb2 allele [1].

References

  1. Association of genes encoding beta2 toxin and a collagen binding protein in Clostridium perfringens isolates of porcine origin. Jost, B.H., Billington, S.J., Trinh, H.T., Songer, J.G. Vet. Microbiol. (2006) [Pubmed]
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