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Gene Review:

CBY1 - chibby homolog 1 (Drosophila)

Homo sapiens

Synonyms: ARB1, ARPP-binding protein, C22orf2, CBY, Cby, ...

Witzgall, R., Gad, S. et al., Bennett, C.B. et al., Jeffries, D.

Witzgall, Gad, Teboul, Lièvre, Goasguen, Berger, Beaune, Laurent-Puig,

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Disease relevance of CBY1

The C22orf2 gene coding Chibby is located on chromosome 22, a region recurrently lost in colorectal cancer [1].

High impact information on CBY1

The differences in survival levels appear to be due to the rapid degradation of the plasmid in the CBY strain [2].
Using the COOH-terminus of polycystin-2 in a two-hybrid screen, my group has identified a novel coiled-coil protein which we call PIGEA-14 (polycystin-2 interactor, Golgi- and endoplasmic reticulum-associated protein with a molecular weight of 14 kDa) [3].
PGEA is dead, long live PGE [4]!
RESULTS: Loss of heterozygosity involving the C22orf2 region was detected in 11 out of 36 patients (30%) [1].

References

Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ? Gad, S., Teboul, D., Lièvre, A., Goasguen, N., Berger, A., Beaune, P., Laurent-Puig, P. BMC Cancer (2004) [Pubmed]
A double-strand break within a yeast artificial chromosome (YAC) containing human DNA can result in YAC loss, deletion or cell lethality. Bennett, C.B., Westmoreland, T.J., Snipe, J.R., Resnick, M.A. Mol. Cell. Biol. (1996) [Pubmed]
Polycystin-2--an intracellular or plasma membrane channel? Witzgall, R. Naunyn Schmiedebergs Arch. Pharmacol. (2005) [Pubmed]
PGEA is dead, long live PGE! Jeffries, D. The British journal of general practice : the journal of the Royal College of General Practitioners. (2005) [Pubmed]

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