Chemical Compound Review:
Ageflex PGE 2-(phenoxymethyl)oxirane
Synonyms:
NSC-635, CCRIS 738, ARONIS24212, NSC635, LS-668, ...
- Lymphokine-mediated bone resorption requires endogenous prostaglandin synthesis. Bockman, R.S., Repo, M.A. J. Exp. Med. (1981)
- Amelioration of B16F10 melanoma lung metastasis in mice by a combination therapy with indomethacin and interleukin 2. Parhar, R.S., Lala, P.K. J. Exp. Med. (1987)
- Gastric mucosal prostaglandin E levels in patients with gastric ulcer disease and carcinoma. Wright, J.P., Young, G.O., Klaff, L.J., Weers, L.A., Price, S.K., Marks, I.N. Gastroenterology (1982)
- Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine. Sharon, P., Ligumsky, M., Rachmilewitz, D., Zor, U. Gastroenterology (1978)
- Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Jakobsson, P.J., Thorén, S., Morgenstern, R., Samuelsson, B. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Identification of a down-regulated mRNA transcript in corpus cavernosum from diabetic patients with erectile dysfunction. Autieri, M.V., Melman, A., Christ, G.J. Int. J. Impot. Res. (1996)
- Platelet-derived growth factor elicits cyclic AMP accumulation in Swiss 3T3 cells: role of prostaglandin production. Rozengurt, E., Stroobant, P., Waterfield, M.D., Deuel, T.F., Keehan, M. Cell (1983)
- Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Kabashima, K., Sakata, D., Nagamachi, M., Miyachi, Y., Inaba, K., Narumiya, S. Nat. Med. (2003)
- Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Rossi, A., Kapahi, P., Natoli, G., Takahashi, T., Chen, Y., Karin, M., Santoro, M.G. Nature (2000)
- Prostaglandin synthesis in different phases of phagocytosis in lung macrophages. Hsueh, W., Gonzalez-Crussi, F., Hanneman, E. Nature (1980)
- Human synovium releases a factor which stimulates chondrocyte production of PGE and plasminogen activator. Meats, J.E., McGuire, M.B., Russell, R.G. Nature (1980)
- Developmental aspects of the renal response to hypoxemia in the lamb fetus. Robillard, J.E., Weitzman, R.E., Burmeister, L., Smith, F.G. Circ. Res. (1981)
- Regulation of agonist-induced prostaglandin E1 versus prostaglandin E2 production. A mass analysis. Rubin, D., Laposata, M. J. Biol. Chem. (1991)
- A prostaglandin E receptor coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rabbit cortical collecting tubule cells. Sonnenburg, W.K., Zhu, J.H., Smith, W.L. J. Biol. Chem. (1990)
- Decreased adrenergic responses in lymphocytes and granulocytes in atopic eczema. Busse, W.W., Lee, T.P. J. Allergy Clin. Immunol. (1976)
- Stimulated gastric prostaglandin output, and the effect of inhibition of prostaglandin synthetase, in the conscious cat. Baker, R., Jaffe, B.M., Shaw, B., Venables, C.W. J. Physiol. (Lond.) (1981)
- Calcium-dependent stimulation of platelet aggregation by PGE. MacIntyre, D.E., Gordon, J.L. Nature (1975)
- Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell. Goodwin, J.S., Bankhurst, A.D., Messner, R.P. J. Exp. Med. (1977)
- Regulation of arachidonic acid metabolites in macrophages. Scott, W.A., Zrike, J.M., Hamill, A.L., Kempe, J., Cohn, Z.A. J. Exp. Med. (1980)
- Interferon and prostaglandins: effects on human natural and lectin-induced cytotoxicity. Lang, N.P., Ortaldo, J.R., Bonnard, G.D., Herberman, R.B. J. Natl. Cancer Inst. (1982)
- ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum. Moeser, A.J., Haskell, M.M., Shifflett, D.E., Little, D., Schultz, B.D., Blikslager, A.T. Gastroenterology (2004)
- Hepatocyte growth factor as a key to modulate anti-ulcer action of prostaglandins in stomach. Takahashi, M., Ota, S., Hata, Y., Mikami, Y., Azuma, N., Nakamura, T., Terano, A., Omata, M. J. Clin. Invest. (1996)
- Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats. Takeuchi, K., Yagi, K., Kato, S., Ukawa, H. Gastroenterology (1997)
- The control of chick myoblast fusion by ion channels operated by prostaglandins and acetylcholine. Entwistle, A., Zalin, R.J., Bevan, S., Warner, A.E. J. Cell Biol. (1988)
- Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation. Yoshida, K., Oida, H., Kobayashi, T., Maruyama, T., Tanaka, M., Katayama, T., Yamaguchi, K., Segi, E., Tsuboyama, T., Matsushita, M., Ito, K., Ito, Y., Sugimoto, Y., Ushikubi, F., Ohuchida, S., Kondo, K., Nakamura, T., Narumiya, S. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Heart adaptation to acute pressure overload: an involvement of endogenous prostaglandins. Chazov, E.I., Pomoinetsky, V.D., Geling, N.G., Orlova, T.R., Nekrasova, A.A., Smirnov, V.N. Circ. Res. (1979)
- Inhibition of prostaglandin synthesis by indomethacin augments the renal vasodilator response to bradykinin in the anesthetized dog. Lonigro, A.J., Hagemann, M.H., Stephenson, A.H., Fry, C.L. Circ. Res. (1978)
- Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2. Caughey, G.E., Cleland, L.G., Penglis, P.S., Gamble, J.R., James, M.J. J. Immunol. (2001)
- Synergistic stimulation of fibroblast prostaglandin production by recombinant interleukin 1 and tumor necrosis factor. Elias, J.A., Gustilo, K., Baeder, W., Freundlich, B. J. Immunol. (1987)
- Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages. Rouzer, C.A., Kingsley, P.J., Wang, H., Zhang, H., Morrow, J.D., Dey, S.K., Marnett, L.J. J. Biol. Chem. (2004)
- Lipopolysaccharide-induced increase of prostaglandin E(2) is mediated by inducible nitric oxide synthase activation of the constitutive cyclooxygenase and induction of membrane-associated prostaglandin E synthase. Devaux, Y., Seguin, C., Grosjean, S., de Talancé, N., Camaeti, V., Burlet, A., Zannad, F., Meistelman, C., Mertes, P.M., Longrois, D. J. Immunol. (2001)
- Luminal NaCl delivery regulates basolateral PGE2 release from macula densa cells. Peti-Peterdi, J., Komlosi, P., Fuson, A.L., Guan, Y., Schneider, A., Qi, Z., Redha, R., Rosivall, L., Breyer, M.D., Bell, P.D. J. Clin. Invest. (2003)
- A novel prostaglandin is the major product of arachidonic acid metabolism in rabbit heart. Isakson, P.C., Raz, A., Denny, S.E., Pure, E., Needleman, P. Proc. Natl. Acad. Sci. U.S.A. (1977)
- Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Trebino, C.E., Stock, J.L., Gibbons, C.P., Naiman, B.M., Wachtmann, T.S., Umland, J.P., Pandher, K., Lapointe, J.M., Saha, S., Roach, M.L., Carter, D., Thomas, N.A., Durtschi, B.A., McNeish, J.D., Hambor, J.E., Jakobsson, P.J., Carty, T.J., Perez, J.R., Audoly, L.P. Proc. Natl. Acad. Sci. U.S.A. (2003)