The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TRAF3IP1  -  TNF receptor-associated factor 3...

Homo sapiens

Synonyms: DKFZP434F124, IFT54, Interleukin-13 receptor alpha 1-binding protein 1, Intraflagellar transport protein 54 homolog, MIP-T3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on TRAF3IP1

  • Although both full-length and mutant DISC1 are found in microtubule fractions, neither form of DISC1 appears to bind directly to microtubules, but rather do so in a MIPT3-dependent fashion that is stabilized by taxol [1].
  • The MIP-T3-TRAF3 interaction requires the coiled-coil TRAF-N domain of TRAF3 [2].
  • MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network [2].
  • These results suggest that MIP-T3 is a novel inhibitor of IL-13 signaling and may be a useful molecule in ameliorating various conditions in which IL-13 plays a central role [3].

Biological context of TRAF3IP1

  • A novel human IL-13Ralpha1 binding protein (IL13RBP1) has been identified using yeast tri-hybrid system, which was found to encode the same protein as MIP-T3 (microtubule interacting protein that associates with tumor necrosis factor (TNF) receptor associating factor-3 (TRAF3)) [3].

Other interactions of TRAF3IP1

  • MIP-T3 may provide a novel mechanism in sequestering TRAF3 to the cytoskeletal network [2].


WikiGenes - Universities