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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TRAF3IP1  -  TNF receptor-associated factor 3...

Homo sapiens

Synonyms: DKFZP434F124, IFT54, Interleukin-13 receptor alpha 1-binding protein 1, Intraflagellar transport protein 54 homolog, MIP-T3, ...
 
 
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High impact information on TRAF3IP1

  • Although both full-length and mutant DISC1 are found in microtubule fractions, neither form of DISC1 appears to bind directly to microtubules, but rather do so in a MIPT3-dependent fashion that is stabilized by taxol [1].
  • The MIP-T3-TRAF3 interaction requires the coiled-coil TRAF-N domain of TRAF3 [2].
  • MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network [2].
  • These results suggest that MIP-T3 is a novel inhibitor of IL-13 signaling and may be a useful molecule in ameliorating various conditions in which IL-13 plays a central role [3].
 

Biological context of TRAF3IP1

  • A novel human IL-13Ralpha1 binding protein (IL13RBP1) has been identified using yeast tri-hybrid system, which was found to encode the same protein as MIP-T3 (microtubule interacting protein that associates with tumor necrosis factor (TNF) receptor associating factor-3 (TRAF3)) [3].
 

Other interactions of TRAF3IP1

  • MIP-T3 may provide a novel mechanism in sequestering TRAF3 to the cytoskeletal network [2].

References

  1. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Morris, J.A., Kandpal, G., Ma, L., Austin, C.P. Hum. Mol. Genet. (2003) [Pubmed]
  2. MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network. Ling, L., Goeddel, D.V. J. Biol. Chem. (2000) [Pubmed]
  3. MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation. Niu, Y., Murata, T., Watanabe, K., Kawakami, K., Yoshimura, A., Inoue, J., Puri, R.K., Kobayashi, N. FEBS Lett. (2003) [Pubmed]
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