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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation.

To unravel the mechanism of interleukin-13 (IL-13)-specific functions, we sought to identify IL-13 receptor ( IL-13R) binding molecules. A novel human IL-13Ralpha1 binding protein (IL13RBP1) has been identified using yeast tri-hybrid system, which was found to encode the same protein as MIP-T3 (microtubule interacting protein that associates with tumor necrosis factor (TNF) receptor associating factor-3 (TRAF3)). It constitutively associates with IL-13Ralpha1 and suppresses IL-4/13- induced signal transducer and activator of transcription-6 (STAT6) phosphorylation. IL-13- induced STAT6 activation was also inhibited as determined by dual luciferase assay and electrophoretic mobility shift assay (EMSA). These results suggest that MIP-T3 is a novel inhibitor of IL-13 signaling and may be a useful molecule in ameliorating various conditions in which IL-13 plays a central role.[1]

References

  1. MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation. Niu, Y., Murata, T., Watanabe, K., Kawakami, K., Yoshimura, A., Inoue, J., Puri, R.K., Kobayashi, N. FEBS Lett. (2003) [Pubmed]
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