Disease relevance of GAS8

• Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer [1].

High impact information on GAS8

• Consistent with this possibility, we show that the human GAS11 protein contains a 144-amino acid domain that co-localizes with microtubules when fused to the green fluorescent protein and expressed in mammalian cells [2].
• These data suggest that GAS11 is associated with the Golgi apparatus [3].
• This suggests that GAS11 function might not be restricted to the cilium [3].
• In support of this, recombinant GAS11 binds Golgi membranes in vitro [3].
• In COS7 cells, GAS11 is associated with the detergent-insoluble cytoskeleton and exhibits a juxtanuclear localization that overlaps with the pericentrosomal Golgi apparatus [3].

Biological context of GAS8

• This report describes the characterization of a transcript located in this region, the growth arrest-specific 11 (GAS11) gene, which was viewed as a potential tumor suppressor gene due to the expression of its mouse homolog specifically during growth arrest [1].
• This localization is dependent upon intact microtubules and is cell-cycle regulated, such that GAS11 is dispersed throughout the cytoplasm as cells progress through mitosis [3].

Associations of GAS8 with chemical compounds

• GAS11 remains associated with Golgi fragments following depolymerization of cytoplasmic microtubules but is dispersed upon disruption of the Golgi with brefeldin A [3].

References