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Gene Review

GAS8  -  growth arrest-specific 8

Homo sapiens

Synonyms: GAS-11, GAS-8, GAS11, Growth arrest-specific protein 11, Growth arrest-specific protein 8
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Disease relevance of GAS8


High impact information on GAS8

  • Consistent with this possibility, we show that the human GAS11 protein contains a 144-amino acid domain that co-localizes with microtubules when fused to the green fluorescent protein and expressed in mammalian cells [2].
  • These data suggest that GAS11 is associated with the Golgi apparatus [3].
  • This suggests that GAS11 function might not be restricted to the cilium [3].
  • In support of this, recombinant GAS11 binds Golgi membranes in vitro [3].
  • In COS7 cells, GAS11 is associated with the detergent-insoluble cytoskeleton and exhibits a juxtanuclear localization that overlaps with the pericentrosomal Golgi apparatus [3].

Biological context of GAS8


Associations of GAS8 with chemical compounds

  • GAS11 remains associated with Golgi fragments following depolymerization of cytoplasmic microtubules but is dispersed upon disruption of the Golgi with brefeldin A [3].


  1. Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer. Whitmore, S.A., Settasatian, C., Crawford, J., Lower, K.M., McCallum, B., Seshadri, R., Cornelisse, C.J., Moerland, E.W., Cleton-Jansen, A.M., Tipping, A.J., Mathew, C.G., Savnio, M., Savoia, A., Verlander, P., Auerbach, A.D., Van Berkel, C., Pronk, J.C., Doggett, N.A., Callen, D.F. Genomics (1998) [Pubmed]
  2. T lymphocyte-triggering factor of african trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes. Hill, K.L., Hutchings, N.R., Grandgenett, P.M., Donelson, J.E. J. Biol. Chem. (2000) [Pubmed]
  3. Expanding the Role of the Dynein Regulatory Complex to Non-Axonemal Functions: Association of GAS11 with the Golgi Apparatus. Colantonio, J.R., Bekker, J.M., Kim, S.J., Morrissey, K.M., Crosbie, R.H., Hill, K.L. Traffic (2006) [Pubmed]
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