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Gene Review:

SRPK3 - SRSF protein kinase 3

Homo sapiens

Synonyms: MSSK-1, MSSK1, Muscle-specific serine kinase 1, SR-protein-specific kinase 3, STK23, ...

Nakagawa, O. et al., Grunau, C. et al.

Nakagawa, Arnold, Nakagawa, Hamada, Shelton, Kusano, Harris, Childs, Campbell, Richardson, Nishino, Olson,

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Disease relevance of SRPK3

Srpk3-null mice display a new entity of type 2 fiber-specific myopathy with a marked increase in centrally placed nuclei; while transgenic mice overexpressing Srpk3 in skeletal muscle show severe myofiber degeneration and early lethality [1].

High impact information on SRPK3

We conclude that normal muscle growth and homeostasis require MEF2-dependent signaling by Srpk3 [1].
The Srpk3 gene is specifically expressed in the heart and skeletal muscle from embryogenesis to adulthood and is controlled by a muscle-specific enhancer directly regulated by MEF2 [1].
The promoter regions of the SLC6A8, MSSK1 and CDM genes were found to be essentially unmethylated in all tissues, regardless of their relative expression level [2].

Other interactions of SRPK3

Two of the genes, SLC6A8 and MSSK1, are tissue-specifically expressed [2].

References

Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Nakagawa, O., Arnold, M., Nakagawa, M., Hamada, H., Shelton, J.M., Kusano, H., Harris, T.M., Childs, G., Campbell, K.P., Richardson, J.A., Nishino, I., Olson, E.N. Genes Dev. (2005) [Pubmed]
Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes. Grunau, C., Hindermann, W., Rosenthal, A. Hum. Mol. Genet. (2000) [Pubmed]

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SRPK3	Bos taurus
spk-1	Caenorhabditis elegans
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srpk3	Danio rerio
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srpk2	Xenopus (Silurana) tropicalis

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