Disease relevance of bpH1

• The B. pertussis histone homologue, BpH1, varies in size in different strains from 182 to 206 amino acids [1].
• A novel chromatin-forming histone H1 homologue is encoded by a dispensable and growth-regulated gene in Bordetella pertussis [1].

High impact information on bpH1

• Insertion of a kanamycin cassette into the bpH1 gene generates a BpH1 null mutant with phenotypic properties and growth rate similar to those of the wild-type strain, showing that this gene is dispensable [1].
• We report the identification of a protein homologous to a histone H1 in Bordetella pertussis [1].
• An in silico investigation of the Anopheles gambiae genome based on the cDNA sequence from An. stephensi allowed us to map the An. gambiae gene to chromosome 2R, to deduce its exon-intron organization, and to confirm that Exon 3 encodes a C-terminal histone-like extension [2].

References