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Gene Review

sodB  -  superoxide dismutase

Bordetella pertussis Tohama I

 
 
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Disease relevance of sodB

  • A SOD-deficient mutant was obtained by insertional inactivation of sodB in B. pertussis, confirming that there is only one SOD in this organism [1].
  • Thiobarbituric acid (TBA)-reactive substances (TBA.R) and superoxide dismutase (SOD) activity were then monitored in the exudate on the acute phase response in this inflammatory model [2].
 

High impact information on sodB

  • The nucleotide sequence of sodB predicted a 21-kDa protein with homology to manganese- and iron-containing SODs from other organisms [1].
  • In an attempt to identify additional regulatory mechanisms that may modulate virulence gene expression, we investigated the effect of various environmental stimuli on the stability of the bvg-regulated vrg6 and the bvg-independent sodB transcripts [3].

References

 
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