Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

sodB - superoxide dismutase

Bordetella pertussis Tohama I

DeShazer, D. et al., Graeff-Wohlleben, H. et al., Yuda, Y. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of sodB

A SOD-deficient mutant was obtained by insertional inactivation of sodB in B. pertussis, confirming that there is only one SOD in this organism [1].
Thiobarbituric acid (TBA)-reactive substances (TBA.R) and superoxide dismutase (SOD) activity were then monitored in the exudate on the acute phase response in this inflammatory model [2].

High impact information on sodB

The nucleotide sequence of sodB predicted a 21-kDa protein with homology to manganese- and iron-containing SODs from other organisms [1].
In an attempt to identify additional regulatory mechanisms that may modulate virulence gene expression, we investigated the effect of various environmental stimuli on the stability of the bvg-regulated vrg6 and the bvg-independent sodB transcripts [3].

References

Characterization of the gene encoding superoxide dismutase of Bordetella pertussis and construction of a SOD-deficient mutant. DeShazer, D., Bannan, J.D., Moran, M.J., Friedman, R.L. Gene (1994) [Pubmed]
Participation of lipid peroxidation in rat pertussis vaccine pleurisy. III. Thiobarbituric acid (TBA) reactant and lysosomal enzyme. Yuda, Y., Tanaka, J., Hirano, F., Igarashi, K., Satoh, T. Chem. Pharm. Bull. (1991) [Pubmed]
Global regulatory mechanisms affect virulence gene expression in Bordetella pertussis. Graeff-Wohlleben, H., Deppisch, H., Gross, R. Mol. Gen. Genet. (1995) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.