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Gene Review:

Myo7a - myosin VIIA

Rattus norvegicus

Kojima, K. et al., Cristobal, R. et al., Desnos, C. et al., Smits, B.M. et al.

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High impact information on Myo7a

The GTPase Rab27A interacts with myosin-VIIa and myosin-Va via MyRIP or melanophilin and mediates melanosome binding to actin [1].
Candidate gene resequencing identified a point mutation that introduces a premature stopcodon in Myo7a [2].
To demonstrate hair cell-specific gene expression, myosin VIIA, calmodulin and alpha9 nicotinic acetylcholine receptor subunit mRNAs were amplified using reverse transcription-polymerase chain reaction (RT-PCR) [3].
The results of this study showed that neural progenitors obtained from fetal rat CNS generated hair cell immunophenotypes with expression of both epitopes of hair cell marker proteins Brn-3c and myosin VIIa in vitro [4].

References

Rab27A and its effector MyRIP link secretory granules to F-actin and control their motion towards release sites. Desnos, C., Schonn, J.S., Huet, S., Tran, V.S., El-Amraoui, A., Raposo, G., Fanget, I., Chapuis, C., Ménasché, G., de Saint Basile, G., Petit, C., Cribier, S., Henry, J.P., Darchen, F. J. Cell Biol. (2003) [Pubmed]
Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics. Smits, B.M., Peters, T.A., Mul, J.D., Croes, H.J., Fransen, J.A., Beynon, A.J., Guryev, V., Plasterk, R.H., Cuppen, E. Genetics (2005) [Pubmed]
Assessment of differential gene expression in vestibular epithelial cell types using microarray analysis. Cristobal, R., Wackym, P.A., Cioffi, J.A., Erbe, C.B., Roche, J.P., Popper, P. Brain Res. Mol. Brain Res. (2005) [Pubmed]
Generation of inner ear hair cell immunophenotypes from neurospheres obtained from fetal rat central nervous system in vitro. Kojima, K., Tamura, S., Nishida, A.T., Ito, J. Acta oto-laryngologica. Supplementum. (2004) [Pubmed]

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MYO7A	Bos taurus
MYO7A	Canis lupus familiaris
myo7aa	Danio rerio
ck	Drosophila melanogaster
MYO7A	Gallus gallus
MYO7A	Homo sapiens
MYO7A	Macaca mulatta
Myo7a	Mus musculus
MYO7A	Pan troglodytes
myo7a	Xenopus (Silurana) tropicalis

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