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Gene Review

ck  -  crinkled

Drosophila melanogaster

Synonyms: 53D10S, BG:DS00929.11, CG7595, D2, DM7a, ...
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High impact information on ck


Biological context of ck

  • In this manuscript, we compare the complete derived amino acid sequence for D2 to two cloned and sequenced eukaryotic esterases and examine the requirement of the D2 gene product for development [3].

Anatomical context of ck

  • This is a phenocopy of mutations in crinkled, and suggests mutations that cause branched hairs will be in genes that encode products that interact with the actin cytoskeleton [5].

Other interactions of ck

  • Together, our data suggest a key role for ck/myoVIIA in the formation of cellular projections and other actin-based functions required for viability [4].


  1. Dimerized Drosophila myosin VIIa: a processive motor. Yang, Y., Kovács, M., Sakamoto, T., Zhang, F., Kiehart, D.P., Sellers, J.R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila. Todi, S.V., Franke, J.D., Kiehart, D.P., Eberl, D.F. Curr. Biol. (2005) [Pubmed]
  3. Molecular analysis of a developmentally regulated gene required for Dictyostelium aggregation. Rubino, S., Mann, S.K., Hori, R.T., Pinko, C., Firtel, R.A. Dev. Biol. (1989) [Pubmed]
  4. Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA. Kiehart, D.P., Franke, J.D., Chee, M.K., Montague, R.A., Chen, T.L., Roote, J., Ashburner, M. Genetics (2004) [Pubmed]
  5. Distinct roles for the actin and microtubule cytoskeletons in the morphogenesis of epidermal hairs during wing development in Drosophila. Turner, C.M., Adler, P.N. Mech. Dev. (1998) [Pubmed]
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