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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

smo-1  -  Protein SMO-1

Caenorhabditis elegans

 
 
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High impact information on smo-1

  • Here we show the major role of SUMO during the development of the Caenorhabditis elegans reproductive system. smo-1 deletion mutants develop into sterile adults with abnormal somatic gonad, germ line, and vulva [1].
  • SMO-1::GFP reporter is highly expressed in the somatic reproductive system. smo-1 animals lack a vulval-uterine connection as a result of impaired ventral uterine pi-cell differentiation and anchor cell fusion [1].
  • Mutations in the LIN-11 LIM domain transcription factor lead to a uterine phenotype that resembles the smo-1 phenotype [1].

References

  1. The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans. Broday, L., Kolotuev, I., Didier, C., Bhoumik, A., Gupta, B.P., Sternberg, P.W., Podbilewicz, B., Ronai, Z. Genes Dev. (2004) [Pubmed]
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