Gene Review:
Rheb - Ras homolog enriched in brain
Rattus norvegicus
Synonyms:
GTP-binding protein Rheb
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High impact information on Rheb
- Induction of Rheb mRNA following middle cerebral artery occlusion in the rat [1].
- Although the Rheb mRNA induction in the medial striatum and hippocampal formation decreased after 8h of occlusion, it still remained significant at 24h of occlusion [1].
- In situ hybridization autoradiography showed that Rheb mRNA was induced in the extensive regions of cerebral cortex and medial striatum surrounding the ischemic region and bilateral hippocampal formation following MCA occlusion [1].
- Rheb is a recently identified member of the Ras super-family and is an immediate early gene that is rapidly and transiently induced in the hippocampal granule cells by NMDA-dependent synaptic activity in the long term potentiation paradigm [1].
References
- Induction of Rheb mRNA following middle cerebral artery occlusion in the rat. Kinouchi, H., Arai, S., Kamii, H., Izaki, K., Kunizuka, H., Mizoi, K., Yoshimoto, T. Neuroreport (1999) [Pubmed]
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