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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ZBTB32  -  zinc finger and BTB domain containing 32

Homo sapiens

Synonyms: FANCC-interacting protein, FAXF, FAZF, Fanconi anemia zinc finger protein, Rog, ...
 
 
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Disease relevance of ZBTB32

  • A comparison of the PLZF, Bcl-6, and the FAZF (Fanconi anemia zinc finger)/ROG protein shows that variations in the BTB pocket result in differential affinity for corepressors, which predicts the potency of transcriptional repression [1].
 

High impact information on ZBTB32

  • We also show that FAZF and wild-type FANCC can colocalize in nuclear foci, whereas a patient-derived mutant FANCC that is compromised for nuclear localization cannot [2].
  • We show that the novel gene, FAZF, encodes a 486 amino acid protein containing a conserved amino terminal BTB/POZ protein interaction domain and three C-terminal Krüppel-like zinc fingers [2].
  • The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific [3].
  • Using a FAZF-inducible myeloid cell line, we found that enforced expression of FAZF was accompanied by accumulation in the G(1) phase of the cell cycle followed later by apoptosis [3].
  • These results suggest an essential role for FAZF during the proliferative stages of primitive hematopoietic progenitors, possibly acting in concert with (a subset of) the Fanconi anemia proteins [3].
 

Biological context of ZBTB32

  • Consistent with its presumed role as a transcriptional repressor, FAZF was found in the nuclear compartment, where it resides in distinct nuclear speckles at or near sites of DNA replication [3].
  • Here we used a novel two-dimensional electrophoretic mobility shift assay (2D-EMSA) procedure for identification and mapping of 52 PTS within a 563-kb human genome region located between the FXYD5 and TZFP genes [4].
 

Anatomical context of ZBTB32

 

Physical interactions of ZBTB32

  • We show that FAZF is a transcriptional repressor that is able to bind to the same DNA target sequences as PLZF [2].
 

Other interactions of ZBTB32

  • Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP [5].

References

  1. Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors. Melnick, A., Carlile, G., Ahmad, K.F., Kiang, C.L., Corcoran, C., Bardwell, V., Prive, G.G., Licht, J.D. Mol. Cell. Biol. (2002) [Pubmed]
  2. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Hoatlin, M.E., Zhi, Y., Ball, H., Silvey, K., Melnick, A., Stone, S., Arai, S., Hawe, N., Owen, G., Zelent, A., Licht, J.D. Blood (1999) [Pubmed]
  3. The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific. Dai, M.S., Chevallier, N., Stone, S., Heinrich, M.C., McConnell, M., Reuter, T., Broxmeyer, H.E., Licht, J.D., Lu, L., Hoatlin, M.E. J. Biol. Chem. (2002) [Pubmed]
  4. Identification and mapping of DNA binding proteins target sequences in long genomic regions by two-dimensional EMSA. Chernov, I.P., Akopov, S.B., Nikolaev, L.G., Sverdlov, E.D. BioTechniques (2006) [Pubmed]
  5. Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP. Lin, W., Lai, C.H., Tang, C.J., Huang, C.J., Tang, T.K. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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