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Gene Review

UL39  -  ribonucleotide reductase subunit 1

Human herpesvirus 1

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Disease relevance of UL39


High impact information on UL39

  • AFP-alb/UL39 transfection increased G207 cytotoxicity 93% in Hep3B (P < 0.0005), with no significant increase in PLC5 [5].
  • This mutant virus, designated RR1CAT/RR2lacZ, was engineered so that coding sequences of the genes UL39 and UL40 specifying the subunits of the viral ribonucleotide reductase were replaced by the chloramphenicol acetyltransferase (CAT) and the lacZ gene coding sequences, respectively [6].
  • Herpes simplex virus type 1 ribonucleotide reductase large subunit: regions of the protein essential for subunit interaction and dimerization [7].

Analytical, diagnostic and therapeutic context of UL39

  • Combining CEA E-P/UL39 with G207 in LS174T flank tumors resulted in a 65% decrease in tumor volume versus G207, phosphate-buffered saline, or'CEA E-P/UL39 alone ( P <.0001) [8].


  1. Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan. Tyminski, E., Leroy, S., Terada, K., Finkelstein, D.M., Hyatt, J.L., Danks, M.K., Potter, P.M., Saeki, Y., Chiocca, E.A. Cancer Res. (2005) [Pubmed]
  2. The effects of interferon-alpha and acyclovir on herpes simplex virus type-1 ribonucleotide reductase. O'Brien, W.J., Narasimhan, J., Guy, J., Tom, P., Taylor, J.L. Antiviral Res. (1998) [Pubmed]
  3. Sequences of the ribonucleotide reductase-encoding genes of equine herpesvirus 4. Riggio, M.P., Onions, D.E. Gene (1994) [Pubmed]
  4. The unique N terminus of herpes simplex virus type 1 ribonucleotide reductase large subunit is phosphorylated by casein kinase 2, which may have a homologue in Escherichia coli. Conner, J. J. Gen. Virol. (1999) [Pubmed]
  5. Utilizing alpha-fetoprotein expression to enhance oncolytic viral therapy in hepatocellular carcinoma. Pin, R.H., Reinblatt, M., Fong, Y. Ann. Surg. (2004) [Pubmed]
  6. Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain. Ramakrishnan, R., Fink, D.J., Jiang, G., Desai, P., Glorioso, J.C., Levine, M. J. Virol. (1994) [Pubmed]
  7. Herpes simplex virus type 1 ribonucleotide reductase large subunit: regions of the protein essential for subunit interaction and dimerization. Conner, J., Furlong, J., Murray, J., Meighan, M., Cross, A., Marsden, H., Clements, J.B. Biochemistry (1993) [Pubmed]
  8. Carcinoembryonic antigen directed herpes viral oncolysis improves selectivity and activity in colorectal cancer. Reinblatt, M., Pin, R.H., Fong, Y. Surgery (2004) [Pubmed]
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