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Gene Review

UL50  -  deoxyuridine triphosphatase

Human herpesvirus 1

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Disease relevance of UL50

  • The coding region of the HSV-1 dUTPase gene, UL 50, was positioned downstream of the promoter and the ribosome-binding site of the phage T7 gene 10 on the expression vector pET-3a [1].

High impact information on UL50

  • Thus, both the kinetics and relative abundance of UL50 and UL37 transcripts are a direct function of their respective promoter regulatory elements [2].
  • In contrast, the only functional elements crucial for expression from the UL50 promoter were the TATA box (-25 to -31) and an Sp1 binding site at -117 bp relative to the cap site [2].
  • Characterization of mutated UL37 and UL50 promoters in recombinant viruses showed that the functional modules important for expression from these promoters are concentrated upstream of the transcription start site; however the extent and composition of these modules in terms of the cis-acting elements they contain was different for each [2].


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