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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

B9D1  -  B9 protein domain 1

Homo sapiens

Synonyms: B9, B9 domain-containing protein 1, EPPB9, MKS1-related protein 1, MKS9, ...
 
 
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Disease relevance of EPPB9

  • These results indicate that myeloid leukemia cell lines express HOX B6 and HOX B9, and that their respective mRNA expressions in NB4 and HL-60 increase at a mid stage of myeloid differentiation by ATRA induction and then decrease during a late stage [1].
  • HOX B6 and HOX B9 mRNAs were also expressed in fresh acute myelocytic leukemia blasts [1].
  • It was determined that HOXB1, B3, B5, B6, B7, B8, and B9 genes are expressed in normal adult cervical epithelium and squamous cervical carcinomas [2].
 

High impact information on EPPB9

  • After the PHA stimulus, HOXB gene activation initiates coordinately as a rapid induction wave in the 3'-->5' cluster direction (i.e., from HOXB1 through B9 genes) [3].

References

  1. Modulation of homeobox B6 and B9 genes expression in human leukemia cell lines during myelomonocytic differentiation. Ohnishi, K., Tobita, T., Sinjo, K., Takeshita, A., Ohno, R. Leuk. Lymphoma (1998) [Pubmed]
  2. HOXB homeobox gene expression in cervical carcinoma. López, R., Garrido, E., Piña, P., Hidalgo, A., Lazos, M., Ochoa, R., Salcedo, M. Int. J. Gynecol. Cancer (2006) [Pubmed]
  3. Coordinate expression and proliferative role of HOXB genes in activated adult T lymphocytes. Carè, A., Testa, U., Bassani, A., Tritarelli, E., Montesoro, E., Samoggia, P., Cianetti, L., Peschle, C. Mol. Cell. Biol. (1994) [Pubmed]
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