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Gene Review

SC101p5  -  transposase

Salmonella typhimurium

 
 
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Disease relevance of SC101p5

 

High impact information on SC101p5

  • The most prevalent variant was SGI1-A (85%), which harbors within the SGI1 complex class 1 integron a common region (CR1) containing orf513, a putative transposase gene, adjacent to the dfrA10 trimethoprim resistance gene [2].
  • The biased endpoint selection may reflect the limited search for target DNA sequences by the Tn10 transposase, and the spatial proximity of the donor and target regions in the folded S. typhimurium nucleoid [3].
  • The method yields single insertion mutants that lack transposase and are not subject to further transposition or chromosome rearrangement [4].
  • Mutations in elements IS1230A and B resulted in frameshifts in the open reading frames that encoded a putative transposase to be inactive [5].

References

  1. Evolutionary dynamics of insertion sequences in Helicobacter pylori. Kalia, A., Mukhopadhyay, A.K., Dailide, G., Ito, Y., Azuma, T., Wong, B.C., Berg, D.E. J. Bacteriol. (2004) [Pubmed]
  2. Salmonella genomic island 1 multidrug resistance gene clusters in Salmonella enterica serovar Agona isolated in Belgium in 1992 to 2002. Doublet, B., Butaye, P., Imberechts, H., Boyd, D., Mulvey, M.R., Chaslus-Dancla, E., Cloeckaert, A. Antimicrob. Agents Chemother. (2004) [Pubmed]
  3. Endpoint bias in large Tn10-catalyzed inversions in Salmonella typhimurium. Krug, P.J., Gileski, A.Z., Code, R.J., Torjussen, A., Schmid, M.B. Genetics (1994) [Pubmed]
  4. Transitory cis complementation: a method for providing transposition functions to defective transposons. Hughes, K.T., Roth, J.R. Genetics (1988) [Pubmed]
  5. Sequence analysis and distribution in Salmonella enterica serovars of IS3-like elements. Collighan, R.J., Walker, S.L., Woodward, M.J. Int. J. Med. Microbiol. (2000) [Pubmed]
 
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