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Gene Review:

DISC2 - disrupted in schizophrenia 2 (non-protein...

Homo sapiens

Synonyms: DISC1-AS1, DISC1OS, NCRNA00015

Millar, J.K. et al., Kato, T., Devon, R.S. et al., Millar, J.K. et al., Hennah, W. et al., et al.

Kato, Millar, Wilson-Annan, Anderson, Christie, Taylor, Semple, Devon, Clair, Muir, Blackwood, Porteous, Hodgkinson, Goldman, Jaeger, Persaud, Kane, Lipsky, Malhotra, Millar, Christie, Semple, Porteous, Millar, James, Brandon, Thomson,

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Psychiatry related information on DISC2

Additionally, a number of independent genetic studies highlight the region of chromosome 1q containing DISC1 and DISC2 as a likely susceptibility locus for both schizophrenia and affective disorders [1].
Using patients from a pedigree in which schizophrenia, depression or bipolar disorder have been linked with a balanced translocation at 1 and 11, candidate pathogenetic genes were cloned as DISC1 (disrupted in schizophrenia-1) and DISC2 [2].
CONCLUSIONS: The DISC-2 is a reliable and economical tool for assessing child psychopathology [3].
Across DISC-2 studies, test-retest reliability of the parents' reports improved for anxiety and depressive disorders [4].

High impact information on DISC2

The Disrupted in Schizophrenia 1 (DISC1) gene, on chromosome 1q42, was originally discovered and linked to schizophrenia in a Scottish kindred carrying a balanced translocation that disrupts DISC1 and DISC2 [5].
In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes TRAX, DISC1 and DISC2, using a study sample of 458 Finnish families ascertained for schizophrenia [6].
Overall, it is clear from the combination of genetic and functional data that DISC1 and/or DISC2 are emerging as important factors in the molecular genetics of psychiatric illness [1].

Biological context of DISC2

Two candidate genes, DISC1 and DISC2 on chromosome 1, are disrupted by a translocation that segregates with major psychiatric illness [7].
A scan of the coding sequence, intron/exon boundaries, and part of the 5' and 3' untranslated regions of DISC1, plus 2.7 kb at the 3' end of DISC2, has revealed a novel microsatellite and 15 novel single nucleotide polymorphisms (SNPs) [8].

Other interactions of DISC2

DISC2 apparently specifies a non-coding RNA molecule that is antisense to DISC1, an arrangement that has been observed at other loci where it is thought that the antisense RNA is involved in regulating expression of the sense gene [9].

Analytical, diagnostic and therapeutic context of DISC2

Reliability and validity of the Dominic questionnaire were studied in Parent DISC-2 positive and negative outpatient and general population samples and against clinical judgement [10].

References

DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. Millar, J.K., James, R., Brandon, N.J., Thomson, P.A. Ann. Med. (2004) [Pubmed]
Molecular genetics of bipolar disorder. Kato, T. Neurosci. Res. (2001) [Pubmed]
The NIMH Diagnostic Interview Schedule for Children Version 2.3 (DISC-2.3): description, acceptability, prevalence rates, and performance in the MECA Study. Methods for the Epidemiology of Child and Adolescent Mental Disorders Study. Shaffer, D., Fisher, P., Dulcan, M.K., Davies, M., Piacentini, J., Schwab-Stone, M.E., Lahey, B.B., Bourdon, K., Jensen, P.S., Bird, H.R., Canino, G., Regier, D.A. Journal of the American Academy of Child and Adolescent Psychiatry. (1996) [Pubmed]
Diagnostic Interview Schedule for Children (DISC-2.25) in Quebec: reliability findings in light of the MECA study. Breton, J.J., Bergeron, L., Valla, J.P., Berthiaume, C., St-Georges, M. Journal of the American Academy of Child and Adolescent Psychiatry. (1998) [Pubmed]
Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Hodgkinson, C.A., Goldman, D., Jaeger, J., Persaud, S., Kane, J.M., Lipsky, R.H., Malhotra, A.K. Am. J. Hum. Genet. (2004) [Pubmed]
Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects. Hennah, W., Varilo, T., Kestilä, M., Paunio, T., Arajärvi, R., Haukka, J., Parker, A., Martin, R., Levitzky, S., Partonen, T., Meyer, J., Lönnqvist, J., Peltonen, L., Ekelund, J. Hum. Mol. Genet. (2003) [Pubmed]
Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia. Millar, J.K., Christie, S., Semple, C.A., Porteous, D.J. Genomics (2000) [Pubmed]
Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder. Devon, R.S., Anderson, S., Teague, P.W., Burgess, P., Kipari, T.M., Semple, C.A., Millar, J.K., Muir, W.J., Murray, V., Pelosi, A.J., Blackwood, D.H., Porteous, D.J. Psychiatr. Genet. (2001) [Pubmed]
Disruption of two novel genes by a translocation co-segregating with schizophrenia. Millar, J.K., Wilson-Annan, J.C., Anderson, S., Christie, S., Taylor, M.S., Semple, C.A., Devon, R.S., Clair, D.M., Muir, W.J., Blackwood, D.H., Porteous, D.J. Hum. Mol. Genet. (2000) [Pubmed]
A structured pictorial questionnaire to assess DSM-III-R-based diagnoses in children (6-11 years): development, validity, and reliability. Valla, J.P., Bergeron, L., Bérubé, H., Gaudet, N., St-Georges, M. Journal of abnormal child psychology. (1994) [Pubmed]

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