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Gene Review

BMP10  -  bone morphogenetic protein 10

Homo sapiens

Synonyms: BMP-10, Bone morphogenetic protein 10
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High impact information on BMP10

  • Recently, we generated a novel transgenic mouse model (alphaMHC-BMP10) in which the cardiac-specific growth factor bone morphogenetic protein 10 (BMP10) is overexpressed in postnatal myocardium [1].
  • These alphaMHC-BMP10 mice appear to have normal cardiogenesis throughout embryogenesis, but develop to smaller hearts within 6 weeks after birth. alphaMHC-BMP10 hearts are about half the normal size with 100% penetrance [1].
  • A statistical analysis showed that n-Bone% with OCP/BMP was significantly higher than that with OCP at both time points, whereas the difference in n-Bone% between OCP/BMP 10 microg and OCP/BMP 1 microg was not significant [2].
  • 15 mg of OCP combined with 10 microg of rhBMP-2 (OCP/BMP 10 microg), 2 [2].


  1. Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth. Chen, H., Yong, W., Ren, S., Shen, W., He, Y., Cox, K.A., Zhu, W., Li, W., Soonpaa, M., Payne, R.M., Franco, D., Field, L.J., Rosen, V., Wang, Y., Shou, W. J. Biol. Chem. (2006) [Pubmed]
  2. New scaffold for recombinant human bone morphogenetic protein-2. Kamakura, S., Nakajo, S., Suzuki, O., Sasano, Y. Journal of biomedical materials research. Part A. (2004) [Pubmed]
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