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Gene Review

Dup99B  -  Ductus ejaculatorius peptide 99B

Drosophila melanogaster

Synonyms: CG33495, DUP, DUP99B, Dmel\CG33495, anon-SAGE:Wang-013
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Disease relevance of Dup99B

  • We found that in adult females radiolabeled SP and DUP99B bind to peripheral nerves, the subesophageal ganglion, the cervical connective, to discrete parts of the thoracic ganglion, and to the genital tract [1].

Psychiatry related information on Dup99B


High impact information on Dup99B

  • Sex-Peptide (SP) and the peptide DUP99B elicit two postmating responses in Drosophila melanogaster females: receptivity is reduced and oviposition is increased [2].
  • The presence of high-affinity SP and DUP99B binding sites in the female were investigated by incubation of cryostat tissue sections with (125)I-iodinated peptides and subsequent autoradiography [1].
  • The DUP99B that is synthesized in the ejaculatory duct is transferred, during mating, into the female genital tract [3].
  • Injected into virgin females, DUP99B elicits the same postmating responses as sex-peptide (increased oviposition, reduced receptivity) [4].
  • Homologies in the coding regions of the two exons of DUP99B and sex-peptide, respectively, suggest that the two genes have evolved by gene duplication [4].


  1. Binding sites of Drosophila melanogaster sex peptide pheromones. Ottiger, M., Soller, M., Stocker, R.F., Kubli, E. J. Neurobiol. (2000) [Pubmed]
  2. Sex-peptides bind to two molecularly different targets in Drosophila melanogaster females. Ding, Z., Haussmann, I., Ottiger, M., Kubli, E. J. Neurobiol. (2003) [Pubmed]
  3. The sex-peptide DUP99B is expressed in the male ejaculatory duct and in the cardia of both sexes. Rexhepaj, A., Liu, H., Peng, J., Choffat, Y., Kubli, E. Eur. J. Biochem. (2003) [Pubmed]
  4. Ductus ejaculatorius peptide 99B (DUP99B), a novel Drosophila melanogaster sex-peptide pheromone. Saudan, P., Hauck, K., Soller, M., Choffat, Y., Ottiger, M., Spörri, M., Ding, Z., Hess, D., Gehrig, P.M., Klauser, S., Hunziker, P., Kubli, E. Eur. J. Biochem. (2002) [Pubmed]
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