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Gene Review

Cyp4a12a  -  cytochrome P450, family 4, subfamily a,...

Mus musculus

Synonyms: BC025936, CYPIVA12, Cyp4a12, Cytochrome P450 4A12A
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High impact information on Cyp4a12

  • Thus, PPARalpha has a specific effect on constitutive expression of Cyp4a12 [1].
  • We set out to find if the strain-specific, male-specific hepatic expression of Cyp4a protein in mouse was due to expression of Cyp4a12 and to understand the genetic basis for reported differences in expression [1].
  • To further investigate genetic factors that control male-specific Cyp4a12 expression, PPARalpha+/+ and -/- mice were studied, showing that total P450 and 12-LAH activity was male-specific in +/+, but not -/- mice [1].
  • However, the male-specific Slp and MUP-1 genes retained hepatic male-specific levels of expression in +/+ and -/- mice, showing that the decrease in Cyp4a12 was not a general effect on male-specific expression [1].
  • Lung levels of Cyp4a12 mRNA were enhanced by ninefold in mice treated with clofibrate and by fourfold in animals injected with IL-1beta [2].

Biological context of Cyp4a12

  • Transcript profiling using macroarrays containing approximately 1200 genes showed that 93% (40 out of 43) of all expression changes observed in wild-type mice upon TCE exposure were dependent on PPARalpha and included known targets of PP (Cyp4a12, epidermal growth factor receptor) and additional genes involved in cell growth [3].

Analytical, diagnostic and therapeutic context of Cyp4a12


  1. Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver. Jeffery, B., Choudhury, A.I., Horley, N., Bruce, M., Tomlinson, S.R., Roberts, R.A., Gray, T.J., Barrett, D.A., Shaw, P.N., Kendall, D., Bell, D.R. Arch. Biochem. Biophys. (2004) [Pubmed]
  2. Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta. Le Bouquin, R., Lugnier, A., Frossard, N., Pons, F. Fundamental & clinical pharmacology. (2004) [Pubmed]
  3. Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver. Laughter, A.R., Dunn, C.S., Swanson, C.L., Howroyd, P., Cattley, R.C., Corton, J.C. Toxicology (2004) [Pubmed]
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