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Gene Review:

CYP4A22 - cytochrome P450, family 4, subfamily A,...

Homo sapiens

Synonyms: CYPIVA22, Cytochrome P450 4A22, Fatty acid omega-hydroxylase, Lauric acid omega-hydroxylase

Bellamine, A. et al., Savas, U. et al., Hiratsuka, M. et al.

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High impact information on CYP4A22

To investigate genetic variation in CYP4A22 in 191 Japanese subjects, we used denaturing HPLC (DHPLC) and direct sequencing [1].
Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population [1].
Comparison between the cDNA sequence of CYP4A11 and that deduced from a published genomic clone suggested the presence of an additional CYP4A gene in humans, CYP4A22 [2].
Wy14643 or dexamethasone induction of CYP4A22 mRNA was not evident in either control or PPARalpha -E282G-expressing HepG2 cells [3].

Regulatory relationships of CYP4A22

Quantitative real-time PCR determined that CYP4A22 mRNA is expressed at significantly lower levels than CYP4A11 mRNA in human liver samples [3].

Analytical, diagnostic and therapeutic context of CYP4A22

Sequence and Southern blot analysis showed the presence in humans of two highly homologous CYP4A genes, CYP4A11 and CYP4A22 [2].

References

Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population. Hiratsuka, M., Nozawa, H., Katsumoto, Y., Moteki, T., Sasaki, T., Konno, Y., Mizugaki, M. Mutat. Res. (2006) [Pubmed]
Characterization of the CYP4A11 gene, a second CYP4A gene in humans. Bellamine, A., Wang, Y., Waterman, M.R., Gainer, J.V., Dawson, E.P., Brown, N.J., Capdevila, J.H. Arch. Biochem. Biophys. (2003) [Pubmed]
Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone. Savas, U., Hsu, M.H., Johnson, E.F. Arch. Biochem. Biophys. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

CYP715A1	Arabidopsis thaliana
CYP4A11	Bos taurus
CYP4A22	Bos taurus
CYP4A11	Canis lupus familiaris
CYP4A37	Canis lupus familiaris
CYP4A38	Canis lupus familiaris
CYP4B1	Gallus gallus
LOC709461	Macaca mulatta
Cyp4a12b	Mus musculus
Cyp4a12a	Mus musculus
Os02g0824100	Oryza sativa Japonica Group
LOC456835	Pan troglodytes
Cyp4a8	Rattus norvegicus

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