The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

pol  -  core DNA polymerase of replisome, 3'-5'...

Enterobacteria phage T5

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of pol


High impact information on pol


Chemical compound and disease context of pol


Biological context of pol

  • Because the structural gene for T5 DNA polymerase is estimated to be 2,600 base pairs long, the whole structural gene may reside in these segments [7].
  • T5 DNA polymerase (T5Pol), an essential enzyme for bacteriophage T5 DNA replication, is unusual because of its high processivity and strand-displacing ability [8].
  • The 3' leads to 5' exonuclease associated with T5 DNA polymerase was not very active with nicked DNA, but inhibition of hydrolysis of substituents at 3'-hydroxyl termini by gpD5 could be observed [9].

Other interactions of pol


  1. The highly processive DNA polymerase of bacteriophage T5. Role of the unique N and C termini. Andraos, N., Tabor, S., Richardson, C.C. J. Biol. Chem. (2004) [Pubmed]
  2. Processiveness of DNA polymerases. A comparative study using a simple procedure. Das, S.K., Fujimura, R.K. J. Biol. Chem. (1979) [Pubmed]
  3. T5 DNA polymerase: structural--functional relationships to other DNA polymerases. Leavitt, M.C., Ito, J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  4. Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate. Xu, Y., Potapova, O., Leschziner, A.E., Grindley, N.D., Joyce, C.M. J. Biol. Chem. (2001) [Pubmed]
  5. Properties of overexpressed phage T5 D15 exonuclease. Similarities with Escherichia coli DNA polymerase I 5'-3' exonuclease. Sayers, J.R., Eckstein, F. J. Biol. Chem. (1990) [Pubmed]
  6. Temperature-sensitive DNA polymerase induced by a bacteriophage T5 mutant: relationship between polymerase and exonuclease activities. Fujimura, R.K., Roop, B.C. Biochemistry (1976) [Pubmed]
  7. Physical locus of the DNA polymerase gene and genetic maps of bacteriophage T5 mutants. Fujimura, R.K., Tavtigian, S.V., Choy, T.L., Roop, B.C. J. Virol. (1985) [Pubmed]
  8. Cloning and overexpression of the gene encoding bacteriophage T5 DNA polymerase. Chatterjee, D.K., Fujimura, R.K., Campbell, J.H., Gerard, G.F. Gene (1991) [Pubmed]
  9. Interaction of a DNA-binding protein, the product of gene D5 of bacteriophage T5, with double-stranded DNA: effects on T5 DNA polymerase functions in vitro. Fujimura, R.K., Roop, B.C. J. Virol. (1983) [Pubmed]
WikiGenes - Universities