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Chemical Compound Review

syntapon     1-sulfonatooxydodecane

Synonyms: dupanal, Sulfotex wa, Trepenol WA, Swascol 3L, texapon DL, ...
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Disease relevance of Sodium dodecyl sulfate


High impact information on Sodium dodecyl sulfate

  • The immunogenic Plasmodium knowlesi (H strain) Mr 74,000 protein in membranes of schizont-infected rhesus erythrocytes was purified on a large scale, free of other polypeptides as monitored by dodecyl sulfate polyacrylamide gel electrophoresis and isoelectric focusing [6].
  • A combined high-performance liquid chromatography-sodium dodecyl sulfate-gel electrophoresis method for the study of the phenotypic protein patterns of mature blood granulocytes was previously described [7].
  • Dodecyl sulfate gel electrophoresis of unreduced samples revealed no discernible differences in molecular weight from normal; this implied that in fibrinogen Paris I, the normal fibrinogen architecture of six covalently linked chains per molecule is preserved [8].
  • Furthermore, using a modification of a protein blotting technique in which proteins are not exposed to dodecyl sulfate denaturation, we have found that D1 preferentially binds to A + T-rich double-stranded DNA in vitro, and it is apparently the only abundant nuclear protein in cultured D. melanogaster cells that possesses this property [9].
  • When purified photosynthetic membranes from Rhodopseudomonas sphaeroides were treated with lithium dodecyl sulfate and subjected to polyacrylamide gel electrophoresis at 4 degrees C, up to 11 pigment-protein complexes were resolved [2].

Chemical compound and disease context of Sodium dodecyl sulfate


Biological context of Sodium dodecyl sulfate


Anatomical context of Sodium dodecyl sulfate


Associations of Sodium dodecyl sulfate with other chemical compounds

  • Proteins synthesized were analyzed by two-dimensional polyacrylamide gels; the first dimension used isoelectric focusing in cylinder gels and the second dimension used electrophoresis in a lithium dodecyl sulfate slab gel [21].
  • Stability studies showed that the activity of the rPAI-1 was very stable when stored at temperatures of 25 degrees C or lower, but decayed within hours when stored at 37 degrees C. Sodium dodecyl sulfate treatment, which partially activates the latent form of natural PAI-1, inactivated rPAI-1 [22].
  • A radioactive protein product was detected which co-migrates with reference E3 immunity protein in urea-polyacrylamide gel electrophoresis at pH 8.7 and urea-sodium dodecyl sulfate polyacrylamide gel electrophoresis at pH 7 [23].
  • The complexes formed by antithrombin III with activated bovine Factor X and thrombin have been studied by gel electrophoresis in dodecyl sulfate [24].
  • The phospholipase A2 was solubilized from the 108,000 x g pellet fraction with 0.3% lithium dodecyl sulfate and then purified to homogeneity by successive DEAE-Cellulofine AM, octyl-Sepharose, Cellulofine GCL 300-m, S-Sepharose, and Bio-Gel P-30 chromatographies in the presence of 0.5% 3-[(3-cholamidopropyl)dimethylammonio]-1-propane-sulfonate [25].

Gene context of Sodium dodecyl sulfate

  • DNA polymerase induced by bacteriophage T5ts53, a mutant with temperature-sensitive polymerase, was purified to about 95% purity as judged by dodecyl sulfate gel electrophoresis [26].
  • These results were confirmed by direct visualization of the Mr = 270,000 IGF-II receptor band on dodecyl sulfate gels following affinity labeling with 125I-IGF-II and the cross-linker disuccinimidyl suberate [27].
  • Each protein fraction was then analyzed by diagonal polyacrylamide-sodium dodecyl sulfate gel electrophoresis (Sommer, A., and Traut, R.R. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 3946-3950) [28].
  • The RNAs were translated in the cell-free protein synthesis system from wheat germ, and the catalase T synthesized was isolated by immunoadsorption and polyacrylamide gel electrophoresis in the presence of dodecyl sulfate [29].
  • The IFN-gamma-inducing component of the cell wall was further identified as a proteolytically resistant, non-sodium dodecyl sulfate-soluble component of the mycolylarabinogalactan peptidoglycan [30].

Analytical, diagnostic and therapeutic context of Sodium dodecyl sulfate

  • The light immunoglobulin chains, the regular alpha-chain, and the 90,000-Da chain from monoclonal HC-IgA1 were isolated by preparative dodecyl sulfate-polyacrylamide gel electrophoresis and by repeated gel filtration in dodecyl sulfate-containing buffer [31].
  • These channels are believed to be comprised of dodecyl sulfate-resistant oligomers (heptameric rings) of PA63 seen by electron microscopy of the purified protein [32].
  • Immunoprecipitation of plasma and AF with MAb 6303 and 6305 before nonsodium dodecyl sulfate-electrophoresis and Western ligand blotting revealed different IGFBP-1 isoforms and differential antibody recognition as the cause of this discrepancy [33].
  • The results using Ag(I) as buffer additives in MEKC are also compared to studies utilizing a mixed counterion surfactant of sodium/silver dodecyl sulfate [34].
  • This was demonstrated by dissolving SRV and purified ATPase with lithium dodecyl sulfate, subjecting them to molecular sieve HPLC, and collecting the elution fractions for determination of protein, measurement of 32P-labeled sites, and electrophoretic analysis [35].


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  7. Progressive loss of phenotypic proteins in mature granulocytes before the onset of blast crisis in human chronic myelogenous leukemia. Bednarek, J.M., Knight, R.D., Taylor, G., Evans, W.H. J. Natl. Cancer Inst. (1988) [Pubmed]
  8. Studies on the structural abnormality of fibrinogen Paris I. Mosesson, M.W., Amrani, D.L., Ménaché, D. J. Clin. Invest. (1976) [Pubmed]
  9. Protein D1 preferentially binds A + T-rich DNA in vitro and is a component of Drosophila melanogaster nucleosomes containing A + T-rich satellite DNA. Levinger, L., Varshavsky, A. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
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  11. NMR studies of the influence of dodecyl sulfate on the amide hydrogen exchange kinetics of a micelle-solubilized hydrophobic tripeptide. O'Neil, J.D., Sykes, B.D. Biochemistry (1989) [Pubmed]
  12. Crystallographic studies of protein denaturation and renaturation. 2. Sodium dodecyl sulfate induced structural changes in triclinic lysozyme. Yonath, A., Podjarny, A., Honig, B., Sielecki, A., Traub, W. Biochemistry (1977) [Pubmed]
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  15. Intramyelinic conversion of cerebrosides into acylgalactosylceramides. Theret, N., Bourre, J.M., Fruchart, J.C., Delbart, C. Neurochem. Res. (1989) [Pubmed]
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  17. Phosphorylase phosphatase regulatory subunit. "Western" blotting with immunoglobulins against inhibitor-2 reveals a protein of Mr = 60,000. Gruppuso, P.A., Johnson, G.L., Constantinides, M., Brautigan, D.L. J. Biol. Chem. (1985) [Pubmed]
  18. Cytochrome c1 of bakers' yeast. I. Isolation and properties. Ross, E., Schatz, G. J. Biol. Chem. (1976) [Pubmed]
  19. The cytosolic component p47(phox) is not a sine qua non participant in the activation of NADPH oxidase but is required for optimal superoxide production. Koshkin, V., Lotan, O., Pick, E. J. Biol. Chem. (1996) [Pubmed]
  20. A fully active, two-active-site, single-chain sucrase.isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein. Sjöström, H., Norén, O., Christiansen, L., Wacker, H., Semenza, G. J. Biol. Chem. (1980) [Pubmed]
  21. Influence of 9-beta-D-arabinofuranosyladenine on total protein synthesis and on differential gene expression of unique proteins in the rodent malarial parasite Plasmodium berghei. Ilan, J., Pierce, D.R., Miller, F.W. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  22. Purification and characterization of recombinant plasminogen activator inhibitor-1 from Escherichia coli. Reilly, T.M., Seetharam, R., Duke, J.L., Davis, G.L., Pierce, S.K., Walton, H.L., Kingsley, D., Sisk, W.P. J. Biol. Chem. (1990) [Pubmed]
  23. In vitro synthesis of the E3 immunity protein directed by Col E3 plasmid deoxyribonucleic acid. Sidikaro, J., Masayasu, N. J. Biol. Chem. (1975) [Pubmed]
  24. Dissociation of complexes and their derivatives formed during inhibition of bovine thrombin and activated factor X by antithrombin III. Jesty, J. J. Biol. Chem. (1979) [Pubmed]
  25. Purification and characterization of a membrane-associated phospholipase A2 from rat spleen. Its comparison with a cytosolic phospholipase A2 S-1. Ono, T., Tojo, H., Kuramitsu, S., Kagamiyama, H., Okamoto, M. J. Biol. Chem. (1988) [Pubmed]
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  28. Cross-linking study on protein topography of rat liver 60 S ribosomal subunits with 2-iminothiolane. Uchiumi, T., Kikuchi, M., Terao, K., Ogata, K. J. Biol. Chem. (1985) [Pubmed]
  29. The effect of delta-aminolevulinate on catalase T-messenger RNA levels in delta-aminolevulinate synthase-defective mutants of Saccharomyces cerevisiae. Richter, K., Ammerer, G., Hartter, E., Ruis, H. J. Biol. Chem. (1980) [Pubmed]
  30. Gamma interferon production by bovine gamma delta T cells following stimulation with mycobacterial mycolylarabinogalactan peptidoglycan. Vesosky, B., Turner, O.C., Turner, J., Orme, I.M. Infect. Immun. (2004) [Pubmed]
  31. The molecular organization of the protein HC-IgA complex (HC-IgA). Grubb, A., Méndez, E., Fernandez-Luna, J.L., López, C., Mihaesco, E., Vaerman, J.P. J. Biol. Chem. (1986) [Pubmed]
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  35. Adenosinetriphosphatase site stoichiometry in sarcoplasmic reticulum vesicles and purified enzyme. Barrabin, H., Scofano, H.M., Inesi, G. Biochemistry (1984) [Pubmed]
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